Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons
| العنوان: | Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons |
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| المؤلفون: | Edwin W. McCleskey, David C. Immke |
| المصدر: | Nature Neuroscience. 4:869-870 |
| بيانات النشر: | Springer Science and Business Media LLC, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Patch-Clamp Techniques, Ischemia, Pharmacology, Chest pain, chemistry.chemical_compound, Psalmotoxin, medicine, Animals, Lactic Acid, Neurons, Afferent, Patch clamp, Muscle, Skeletal, Acid-sensing ion channel, Acidosis, Neurons, Dose-Response Relationship, Drug, General Neuroscience, Hydrogen-Ion Concentration, medicine.disease, Rats, Lactic acid, chemistry, Lactic acidosis, COS Cells, Calcium Channels, medicine.symptom, Acids, Neuroscience |
| الوصف: | Lactic acid produced by anaerobic metabolism during cardiac ischemia is among several compounds suggested to trigger anginal chest pain; however, the pH reached when a coronary artery is occluded (pH 7.0 to 6.7) can also occur during systemic acidosis, which causes no chest pain. Here we show that lactate, acting through extracellular divalent ions, dramatically increases activity of an acid-sensing ion channel (ASIC) that is highly expressed on sensory neurons that innervate the heart. The effect should confer upon neurons that express ASICs an extra sensitivity to the lactic acidosis of local ischemia compared to acidity caused by systemic pathology. |
| تدمد: | 1546-1726 1097-6256 |
| DOI: | 10.1038/nn0901-869 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48eeca05540614dfd3657330cd4062a https://doi.org/10.1038/nn0901-869 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a48eeca05540614dfd3657330cd4062a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15461726 10976256 |
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| DOI: | 10.1038/nn0901-869 |