Global Distribution of Invasive Serotype 35D Streptococcus pneumoniae Isolates following Introduction of 13-Valent Pneumococcal Conjugate Vaccine
| العنوان: | Global Distribution of Invasive Serotype 35D Streptococcus pneumoniae Isolates following Introduction of 13-Valent Pneumococcal Conjugate Vaccine |
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| المؤلفون: | Dean Everett, Lesley McGee, Pak-Leung Ho, Susan A. Nzenze, Paulina A. Hawkins, Philip E. Carter, Stuart C. Clarke, Martin Antonio, Stephanie W. Lo, Mignon du Plessis, Sadia Shakoor, Anne von Gottberg, Keith P. Klugman, Ozgen Koseoglu Eser, Stephen D. Bentley, Brenda Kwambana-Adams, Robert F. Breiman, Naima Elmdaghri, Shabir A. Madhi, Rama Kandasamy, Andries J. van Tonder, Jennifer E. Cornick, Rebecca A. Gladstone |
| المصدر: | Journal of clinical microbiology Journal of Clinical Microbiology Lo, S W, Gladstone, R A, van Tonder, A J, Hawkins, P A, Kwambana-Adams, B, Cornick, J E, Madhi, S A, Nzenze, S A, du Plessis, M, Kandasamy, R, Carter, P E, Eser, Ö K, Ho, P L, Elmdaghri, N, Shakoor, S, Clarke, S C, Antonio, M, Everett, D B, von Gottberg, A, Klugman, K P, McGee, L, Breiman, R F & Bentley, S D 2018, ' Global Distribution of Invasive Serotype 35D Streptococcus pneumoniae Isolates following Introduction of 13-Valent Pneumococcal Conjugate Vaccine ', Journal of Clinical Microbiology, vol. 56, no. 7 . https://doi.org/10.1128/JCM.00228-18 |
| بيانات النشر: | American Society for Microbiology, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Serotype, Genotype, Epidemiology, 030106 microbiology, Biology, medicine.disease_cause, Serogroup, Pneumococcal conjugate vaccine, Pneumococcal Infections, Serology, Pneumococcal Vaccines, 03 medical and health sciences, Streptococcus pneumoniae, Drug Resistance, Bacterial, medicine, Prevalence, novel serotype, 35D, Phylogeny, Genetic Variation, Sequence Analysis, DNA, Virology, Stop codon, 3. Good health, 030104 developmental biology, Carriage, whole-genome sequencing, Genes, Bacterial, Carrier State, Mutation, Quellung reaction, PCV, Genome, Bacterial, medicine.drug |
| الوصف: | A newly recognized pneumococcal serotype, 35D, which differs from the 35B polysaccharide in structure and serology by not binding to factor serum 35a, was recently reported. The genetic basis for this distinctive serology is due to the presence of an inactivating mutation in wciG , which encodes an O-acetyltransferase responsible for O-acetylation of a galactofuranose. Here, we assessed the genomic data of a worldwide pneumococcal collection to identify serotype 35D isolates and understand their geographical distribution, genetic background, and invasiveness potential. Of 21,980 pneumococcal isolates, 444 were originally typed as serotype 35B by PneumoCaT. Analysis of the wciG gene revealed 23 isolates from carriage ( n = 4) and disease ( n = 19) with partial or complete loss-of-function mutations, including mutations resulting in premature stop codons ( n = 22) and an in-frame mutation ( n = 1). These were selected for further analysis. The putative 35D isolates were geographically widespread, and 65.2% (15/23) of them was recovered after the introduction of pneumococcal conjugate vaccine 13 (PCV13). Compared with serotype 35B isolates, putative serotype 35D isolates have higher invasive disease potentials based on odds ratios (OR) (11.58; 95% confidence interval[CI], 1.42 to 94.19 versus 0.61; 95% CI, 0.40 to 0.92) and a higher prevalence of macrolide resistance mediated by mefA (26.1% versus 7.6%; P = 0.009). Using the Quellung reaction, 50% (10/20) of viable isolates were identified as serotype 35D, 25% (5/20) as serotype 35B, and 25% (5/20) as a mixture of 35B/35D. The discrepancy between phenotype and genotype requires further investigation. These findings illustrated a global distribution of an invasive serotype, 35D, among young children post-PCV13 introduction and underlined the invasive potential conferred by the loss of O-acetylation in the pneumococcal capsule. |
| وصف الملف: | application/pdf; text |
| اللغة: | English |
| تدمد: | 0095-1137 |
| DOI: | 10.1128/JCM.00228-18 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a476934a2b204dc807e8339c68589715 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a476934a2b204dc807e8339c68589715 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00951137 |
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| DOI: | 10.1128/JCM.00228-18 |