Long-term efficacy of toltrazuril in naïve calves prophylactically treated and experimentally infected with Eimeria spp
| العنوان: | Long-term efficacy of toltrazuril in naïve calves prophylactically treated and experimentally infected with Eimeria spp |
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| المؤلفون: | Dina María Beltrán, Zapa, Luiz Fellipe Monteiro, Couto, Luciana Maffini, Heller, Lorena Lopes, Ferreira, Hariye Victória, Iuasse, Raphaela Barbosa, Naves, Artur Siqueira Nunes, Trindade, Lídia Mendes, De Aquino, Vando Edesio, Soares, Welber Daniel Zanetti, Lopes |
| المصدر: | Parasitology Research. 121:2571-2578 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | General Veterinary, Coccidiosis, Triazines, Oocysts, Cattle Diseases, General Medicine, Feces, Infectious Diseases, Insect Science, Animals, Coccidiostats, Cattle, Eimeria, Parasitology |
| الوصف: | Eimeria are ubiquitous parasites and eimeriosis treatment is based on coccidiostats or coccidicides used prophylactically, metaphylactically, or therapeutically. The long-term efficacy of toltrazuril (TZR, 15 mg/kg) against experimentally infected naïve calves was investigated. Seven groups (six treated and one control) of six animals each were formed. Animals of each group received a single TZR prophylactic oral treatment on days - 42, - 35, - 28, - 21, - 14, and - 7 before the challenge with infectious sporulated oocysts of Eimeria spp. (100,000 oocysts: 59.5% E. zuernii, 38.1% E. bovis, 1.2%, E. alabamensis, and 1.2% E. ellipsoidalis). The long-term efficacy was assessed based on Eimeria spp. oocyst excretion by fecal oocyst counts. Three calves from the control group presented diarrhea with blood, which was not observed in animals belonging to the treatment groups. The TZR achieved efficacy greater than 95.0% up to 14 and 7 days. This formulation showed efficacy above 95% for 7 to 14 days, between 82 and 84% for 21 to 28 days and between 50 and 64% for 35 to 42 days. |
| تدمد: | 1432-1955 0932-0113 |
| DOI: | 10.1007/s00436-022-07601-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a433387bacac77e66174c242486223d1 https://doi.org/10.1007/s00436-022-07601-9 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a433387bacac77e66174c242486223d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321955 09320113 |
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| DOI: | 10.1007/s00436-022-07601-9 |