Evening intake of aspirin is associated with a more stable 24-h platelet inhibition compared to morning intake: a study in chronic aspirin users
| العنوان: | Evening intake of aspirin is associated with a more stable 24-h platelet inhibition compared to morning intake: a study in chronic aspirin users |
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| المؤلفون: | Gerrit Veen, Abel Thijs, Tim Jon Wessels, Jeske Joanna Katarina van Diemen, Yvo M. Smulders, Wessel W. Fuijkschot |
| المساهمون: | Internal medicine, Pathology, ICaR - Circulation and metabolism, Cardiology |
| المصدر: | Platelets, 27(4), 351-356. Informa Healthcare van Diemen, J J K, Fuijkschot, W W, Wessels, T J, Veen, G, Smulders, Y M & Thijs, A 2016, ' Evening intake of aspirin is associated with a more stable 24-h platelet inhibition compared to morning intake : a study in chronic aspirin users ', Platelets, vol. 27, no. 4, pp. 351-356 . https://doi.org/10.3109/09537104.2015.1107536 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Blood Platelets, Male, 0301 basic medicine, medicine.medical_specialty, Time Factors, Evening, Adolescent, Platelet Aggregation, Platelet Function Tests, 030204 cardiovascular system & hematology, Pharmacology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Platelet, Circadian rhythm, Platelet activation, Aged, Morning, Aspirin, business.industry, Hematology, General Medicine, Middle Aged, Crossover study, Regimen, 030104 developmental biology, Endocrinology, Cardiovascular Diseases, Female, business, Platelet Aggregation Inhibitors, medicine.drug |
| الوصف: | Daily generation of novel platelets may compromise aspirin's platelet inhibitory action, especially near the end of the regular 24-h dosing interval. A contributor to this attenuation could be the endogenous circadian rhythm. The primary objective of this study was to assess platelet activity 12 and 24 h after different times of aspirin intake (c.q. 8.00 AM and 8.00 PM). A randomized open-label crossover study was conducted, comprising outpatients with stable cardiovascular disease taking aspirin once daily. We measured platelet aggregation with the platelet function analyzer (PFA)-200(®) and light transmission aggregometry (LTA). The attenuation of aspirin's inhibitory action was most apparent in the 8.00 AM regimen. The platelet function analyzer-closure time was 78 s faster at 24 h than at 12 h after intake in the 8.00 AM regimen (IQR: 166.8-301 vs. 132.8-301; p = 0.006) and 0 s faster at 24 h than at 12 h after intake in the 8.00 PM regimen (IQR: 198.8-837.0 vs. 169.8-301; p = 0.653). The adenosine diphosphate 1.0 µmol/L maximum amplitude was 5.40% higher at 24 h than at 12 h after intake in the 8.00 AM regimen (95% confidence interval (CI): -0.03--10.8; p = 0.040) and was 0.75% higher 24 h than at 12 h after intake in the 8.00 PM regimen (95% CI: -4.83-3.33; p = 0.705). The platelet inhibitory effect of aspirin decreases after 24 h, particularly after intake in the morning. These results suggest that patients might benefit from evening intake or twice daily intake regimens. |
| تدمد: | 1369-1635 0953-7104 |
| DOI: | 10.3109/09537104.2015.1107536 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4326448fa08f00ac6f2a7215c69a9b1 https://doi.org/10.3109/09537104.2015.1107536 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....a4326448fa08f00ac6f2a7215c69a9b1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13691635 09537104 |
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| DOI: | 10.3109/09537104.2015.1107536 |