Mammographic breast density and breast cancer risk in a Mediterranean population: a nested case–control study in the EPIC Florence cohort
| العنوان: | Mammographic breast density and breast cancer risk in a Mediterranean population: a nested case–control study in the EPIC Florence cohort |
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| المؤلفون: | Domenico Palli, D. Ambrogetti, Benedetta Bendinelli, Giovanna Masala, Saverio Caini, Melania Assedi |
| المصدر: | Breast Cancer Research and Treatment. 164:467-473 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, medicine.medical_specialty, Population, Breast Neoplasms, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Odds Ratio, medicine, Humans, Family history, Prospective cohort study, education, Breast Density, Gynecology, education.field_of_study, Mediterranean Region, business.industry, Obstetrics, Odds ratio, Middle Aged, medicine.disease, 030104 developmental biology, Oncology, Case-Control Studies, 030220 oncology & carcinogenesis, Nested case-control study, Cohort, Female, business, Body mass index, Mammography |
| الوصف: | Mammographic breast density (MBD) has been consistently associated with breast cancer (BC) risk, and at the same time it is modulated by established BC risk factors related to reproductive and hormonal history and to lifestyle. We aimed to evaluate the association between the clinical breast imaging reporting and data system (BI-RADS), a qualitative MBD classification used in clinical setting, and BC risk through a case–control nested in the EPIC Florence cohort where baseline information on reproductive history, lifestyle and anthropometry were collected. The study includes 136 newly diagnosed BC cases and 635 controls from the 10,083 healthy women enroled in the cohort between 1993 and 1998 and followed for 6 years on average. MBD was assessed on a negative mammogram performed at least one year before diagnosis in cases and on a mammogram performed in the same period for controls matched for age, enrolment date and menopausal status. Multivariate analyses adjusted for education, body mass index, parity, number of children, breastfeeding, BC family history, history of breast biopsies and Hormone Replacement Therapy use were performed. An increase in BC risk across BI-RADS categories emerged with adjusted odds ratios (OR) 1.79 (95% CI 1.06–3.01), OR 2.09 (95% CI 1.17–3.74) and OR 2.67 (95% CI 1.08–6.62) for categories 2, 3 and 4 in comparison with the reference category (p for trend = 0.008). We confirm in this Mediterranean population the association of increasing MBD, classified according to BI-RADS with BC risk also taking into account other well-known risk factors for this neoplasm. |
| تدمد: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-017-4274-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a419f2d7c0bcb02e630d293234a1d261 https://doi.org/10.1007/s10549-017-4274-9 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a419f2d7c0bcb02e630d293234a1d261 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737217 01676806 |
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| DOI: | 10.1007/s10549-017-4274-9 |