Tumor immune microenvironment modulation-based drug delivery strategies for cancer immunotherapy
| العنوان: | Tumor immune microenvironment modulation-based drug delivery strategies for cancer immunotherapy |
|---|---|
| المؤلفون: | Shuyan Han, Zhipeng Gu, Jun Wu, Keqing Huang |
| المصدر: | Nanoscale. 12:413-436 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_treatment, Immune microenvironment, Biocompatible Materials, 02 engineering and technology, Patient response, Bioinformatics, Immunomodulation, 03 medical and health sciences, Drug Delivery Systems, Immune system, Cancer immunotherapy, Neoplasms, Tumor Microenvironment, medicine, Humans, Immunologic Factors, General Materials Science, 030304 developmental biology, Drug Carriers, 0303 health sciences, business.industry, Neoplasms therapy, Cancer, Immunotherapy, 021001 nanoscience & nanotechnology, medicine.disease, Drug delivery, Nanoparticles, 0210 nano-technology, business |
| الوصف: | The past years have witnessed promising clinical feedback for anti-cancer immunotherapies, which have become one of the hot research topics; however, they are limited by poor delivery kinetics, narrow patient response profiles, and systemic side effects. To the best of our knowledge, the development of cancer is highly associated with the immune system, especially the tumor immune microenvironment (TIME). Based on the comprehensive understanding of the complexity and diversity of TIME, drug delivery strategies focused on the modulation of TIME can be of great significance for directing and improving cancer immunotherapy. This review highlights the TIME modulation in cancer immunotherapy and summarizes the versatile TIME modulation-based cancer immunotherapeutic strategies, medicative principles and accessory biotechniques for further clinical transformation. Remarkably, the recent advances of cancer immunotherapeutic drug delivery systems and future prospects of TIME modulation-based drug delivery systems for much more controlled and precise cancer immunotherapy will be emphatically discussed. |
| تدمد: | 2040-3372 2040-3364 |
| DOI: | 10.1039/c9nr08086d |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a331c059006d4c89abf26a81bda2c055 https://doi.org/10.1039/c9nr08086d |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a331c059006d4c89abf26a81bda2c055 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20403372 20403364 |
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| DOI: | 10.1039/c9nr08086d |