The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors
| العنوان: | The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors |
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| المؤلفون: | Tamera D. Hughes, Osman F. Güner, Emma Carine Iradukunda, Robert S. Phillips, J. Phillip Bowen |
| المصدر: | Molecules Molecules, Vol 27, Iss 273, p 273 (2022) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | KMO inhibitors, Pharmaceutical Science, Alzheimer’s disease (AD), Review, Gene Expression Regulation, Enzymologic, Analytical Chemistry, Structure-Activity Relationship, QD241-441, Kynurenine 3-Monooxygenase, kynurenine pathway (KP), kynurenic acid, Drug Discovery, Animals, Humans, neurodegenerative diseases, Physical and Theoretical Chemistry, Enzyme Inhibitors, Inflammation, Organic Chemistry, kynurenine 3-monooxygenase (KMO), kynurenine, molecular dynamics simulation, Chemistry (miscellaneous), Drug Design, pharmacophore modeling, Molecular Medicine, neuroprotection |
| الوصف: | Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in generating cellular energy and catabolizing tryptophan. Under inflammatory conditions, however, there is an upregulation of the KP enzymes, particularly kynurenine 3-monooxygenase (KMO). KMO has garnered much attention due to its production of toxic metabolites that have been implicated in many diseases and disorders. With many of these illnesses having an inadequate or modest treatment, there exists a need to develop KMO inhibitors that reduce the production of these toxic metabolites. Though prior efforts to find an appropriate KMO inhibitor were unpromising, the development of a KMO crystal structure has provided the opportunity for a rational structure-based design in the development of inhibitors. Therefore, the purpose of this review is to describe the kynurenine pathway, the kynurenine 3-monooxygenase enzyme, and KMO inhibitors and their potential candidacy for clinical use. |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3290fc17b970911fb0903b47920f39f https://pubmed.ncbi.nlm.nih.gov/35011505 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a3290fc17b970911fb0903b47920f39f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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