Epigenetic clock and methylation studies in elephants
| العنوان: | Epigenetic clock and methylation studies in elephants |
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| المؤلفون: | Joseph A. Zoller, Jesús E. Maldonado, Michael G. Campana, Mingjia Yao, Amin Haghani, Steve Horvath, Natalia A. Prado, Ken Raj, Janine L. Brown, Lora Bagryanova, Todd R. Robeck, Dennis L. Schmitt |
| المصدر: | Aging Cell |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Epigenomics, 0301 basic medicine, Aging, Cellular differentiation, Elephants, elephant, Methylation, 03 medical and health sciences, 0302 clinical medicine, Elephas, Animals, Epigenetics, development, Gene, Genetic association, DNA methylation, biology, Original Articles, Cell Biology, biology.organism_classification, 030104 developmental biology, Evolutionary biology, Original Article, epigenetic clock, 030217 neurology & neurosurgery, Bivalent chromatin |
| الوصف: | Age‐associated DNA‐methylation profiles have been used successfully to develop highly accurate biomarkers of age ("epigenetic clocks") in humans, mice, dogs, and other species. Here we present epigenetic clocks for African and Asian elephants. These clocks were developed using novel DNA methylation profiles of 140 elephant blood samples of known age, at loci that are highly conserved between mammalian species, using a custom Infinium array (HorvathMammalMethylChip40). We present epigenetic clocks for Asian elephants (Elephas maximus), African elephants (Loxodonta africana), and both elephant species combined. Two additional human‐elephant clocks were constructed by combining human and elephant samples. Epigenome‐wide association studies identified elephant age‐related CpGs and their proximal genes. The products of these genes play important roles in cellular differentiation, organismal development, metabolism, and circadian rhythms. Intracellular events observed to change with age included the methylation of bivalent chromatin domains, and targets of polycomb repressive complexes. These readily available epigenetic clocks can be used for elephant conservation efforts where accurate estimates of age are needed to predict demographic trends. DNA methylation aging clocks for African and Asian elephants. Some of these clocks apply to humans as well. Parts of the graphic were created by Hollis Burbank‐Hammerlund, Sandra Oviedo, and BioRender.com. |
| تدمد: | 1474-9726 1474-9718 |
| DOI: | 10.1111/acel.13414 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a316536c03b085baede32c528e4bb145 https://doi.org/10.1111/acel.13414 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a316536c03b085baede32c528e4bb145 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14749726 14749718 |
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| DOI: | 10.1111/acel.13414 |