TRPV1 Ion Channel: Structural Features, Activity Modulators, and Therapeutic Potential
| العنوان: | TRPV1 Ion Channel: Structural Features, Activity Modulators, and Therapeutic Potential |
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| المؤلفون: | Oksana Sintsova, Irina Gladkikh, Elena Leychenko, Sergey A. Kozlov |
| المصدر: | Biochemistry (Moscow). 86:S50-S70 |
| بيانات النشر: | Pleiades Publishing Ltd, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Protein Conformation, Biophysics, TRPV1, Pain, TRPV Cation Channels, Mutagenesis (molecular biology technique), Ligands, Biochemistry, Biochemistry, Genetics and Molecular Biology (miscellaneous), 03 medical and health sciences, Animals, Humans, Medicine, Functional studies, Binding site, Ion channel, 0303 health sciences, business.industry, 030302 biochemistry & molecular biology, General Medicine, Channel sensitivity, Drug development, Capsaicin, Geriatrics and Gerontology, business, Neuroscience |
| الوصف: | Although TRPV1 ion channel has been attracting researchers' attention for many years, its functions in animal organisms, the principles of regulation, and the involvement in pathological processes have not yet been fully clarified. Mutagenesis experiments and structural studies have identified the structural features of the channel and binding sites for its numerous ligands; however, these studies are far from conclusion. This review summarizes recent achievements in the TRPV1 research with special focus on structural and functional studies of the channel and on its ligands, which are extremely diverse in their nature and interaction specificity to TRPV1. Particular attention was given to the effects of numerous endogenous agonists and antagonists that can fine-tune the channel sensitivity to its usual activators, such as capsaicin, heat, acids, or their combination. In addition to the pain sensing not covered in this review, the TRPV1 channel was found to be involved in the regulation of many important physiological and pathological processes and, therefore, can be considered as a promising therapeutic target in the treatment of various diseases, such as pneumonia, ischemia, diabetes, epilepsy, schizophrenia, psoriasis, etc. |
| تدمد: | 1608-3040 0006-2979 |
| DOI: | 10.1134/s0006297921140054 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f8bc43ca08220fb6b95996bfc1f7c2 https://doi.org/10.1134/s0006297921140054 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a2f8bc43ca08220fb6b95996bfc1f7c2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16083040 00062979 |
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| DOI: | 10.1134/s0006297921140054 |