The relationship between the leptin/ghrelin ratio and meals with various macronutrient contents in men with different nutritional status: a randomized crossover study
| العنوان: | The relationship between the leptin/ghrelin ratio and meals with various macronutrient contents in men with different nutritional status: a randomized crossover study |
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| المؤلفون: | Adam Kretowski, Joanna Goscik, Edyta Adamska-Patruno, Maria Gorska, Barbara Pietraszewska, Lucyna Ostrowska |
| المصدر: | Nutrition journal, 17:118 Nutrition Journal Nutrition Journal, Vol 17, Iss 1, Pp 1-7 (2018) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Leptin, Male, 0301 basic medicine, Ideal Body Weight, Medicine (miscellaneous), Overweight, Leptin/ghrelin ratio, 0302 clinical medicine, lcsh:RC620-627, Meals, High-fat meal, Meal, Cross-Over Studies, Normo-carbohydrate meal, Nutrition and Dietetics, High-carbohydrate meal, digestive, oral, and skin physiology, Fasting, Middle Aged, Nutrition Surveys, Postprandial Period, Ghrelin, lcsh:Nutritional diseases. Deficiency diseases, Postprandial, Analysis of variance, medicine.symptom, lcsh:Nutrition. Foods and food supply, Adult, medicine.medical_specialty, Nutritional Status, lcsh:TX341-641, 030209 endocrinology & metabolism, Clinical nutrition, Overweight/obesity, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Humans, Obesity, Postprandial state, 030109 nutrition & dietetics, business.industry, Research, Nutrients, Crossover study, Endocrinology, Normal body weight men, business |
| الوصف: | Background Hormones, which influence satiety and hunger, play a significant role in body energy balance regulation. Ghrelin is a peptide that plays an important role in short-term appetite regulation, whereas leptin is a factor that controls long-term energy balance and is considered as a satiety hormone. The aim of this study was to evaluate the leptin/ghrelin ratio in a fasting state and after the intake of meals with varying macronutrient contents and to assess the possible differences between normal body weight and overweight/obese men. Methods We examined 46 healthy adult men (23 with normal body weight and 23 overweight/obese) aged 21–58, who were divided into two groups. In the crossover study, participants received isocaloric (450 kcal) meals with different macronutrient contents: men from the first group received high-carbohydrate (HC) and normo-carbohydrate (NC) meals, and in the second group, participants received high-carbohydrate and high-fat (HF) meals. The ratio of leptin/ghrelin levels was calculated from leptin and total ghrelin serum concentrations in a fasting state and 30, 60, 120, 180 and 240 min after meal intake. One-way ANOVA and Wilcoxon signed-rank tests were carried out. The normality of the variable distribution was checked with the Shapiro–Wilk test, the homogeneity of variances was verified with the Levene test, and the false discovery rate p-value adjustment method was used. Results The leptin/ghrelin ratio was significantly higher in overweight/obese men than individuals with normal body weight in a fasting state, as well as postprandially. We observed trends towards a higher leptin/ghrelin ratio values from the 60 min after HC-meal intake compared to the NC- and HF-meals in normal body weight participants, while in overweight/obese men, we did not note any significant differences dependent on the meal type. Conclusions We have observed a significantly different postprandial leptin/ghrelin ratio in normal body weight and overweight/obese men, and our results suggest that in men with normal body weight, a greater feeling of satiety may occur after high-carbohydrate meal intake, which was not noted in the overweight/obese individuals. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2459026da7579d82b7d92f34b1cd21c https://repository.publisso.de/resource/frl:6416431 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a2459026da7579d82b7d92f34b1cd21c |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |