Acquired Renal Cysts in Five-Sixths Nephrectomized Rats: The Roles of Oxalate Deposits in Renal Tubules and a Renotropic Factor
| العنوان: | Acquired Renal Cysts in Five-Sixths Nephrectomized Rats: The Roles of Oxalate Deposits in Renal Tubules and a Renotropic Factor |
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| المؤلفون: | T Ono, Yukinori Oh, Hiroko Ono, Keiji Ono, Kazuhiko Kikawa |
| المصدر: | Nephron. 51:393-398 |
| بيانات النشر: | S. Karger AG, 1989. |
| سنة النشر: | 1989 |
| مصطلحات موضوعية: | Vitamin, medicine.medical_specialty, medicine.medical_treatment, Ascorbic Acid, Nephron, urologic and male genital diseases, Nephrectomy, Oxalate, chemistry.chemical_compound, Internal medicine, medicine, Animals, Growth Substances, Oxalates, Kidney, Creatinine, Histocytochemistry, business.industry, Rats, Inbred Strains, Kidney Diseases, Cystic, Hyperplasia, Ascorbic acid, medicine.disease, Rats, Kidney Tubules, medicine.anatomical_structure, Endocrinology, chemistry, Intercellular Signaling Peptides and Proteins, Kidney Failure, Chronic, business |
| الوصف: | The present study was undertaken to see if the oxalate deposits seen in renal tubules are a causative factor in the development of acquired renal cysts in chronic renal failure. Thirty 5/6 nephrectomized rats had free access to water containing 8 mg/ml of vitamin C (oxalate precursor) and 20 5/6 nephrectomized rats were given tap water without vitamin C. Oxalate deposits were found on microscopy in the renal tubules of vitamin C-treated rats in the 11th and 12th postnephrectomy months; however, acquired renal cysts were noted far in advance of the appearance of oxalate crystals. It has been suggested that the tubular dilatation seen in 5/6 nephrectomized rats is caused by an abrupt decrease in the functioning renal mass, leading to the production of a so-called 'renotropic factor'. However, oxalate deposits and renal tubular dilatation in oxalate-treated 5/6 nephrectomized rats preceded the renal tubular dilatation of untreated partially nephrectomized rats. In addition, these histological changes in the kidney were also seen in healthy rats which were given oxalate orally and subcutaneously. The present study suggested that the pathogenesis of acquired renal cysts is multifactorial. Renotropic factor may play an important role leading to nephron hyperplasia, but oxalate deposits in the renal tubules seem to be an important factor in the formation of these cysts. |
| تدمد: | 2235-3186 1660-8151 |
| DOI: | 10.1159/000185329 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b83986a956eb98cfd57f6ce8a77569 https://doi.org/10.1159/000185329 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a1b83986a956eb98cfd57f6ce8a77569 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22353186 16608151 |
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| DOI: | 10.1159/000185329 |