Daily Oxygen/O3 Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise
| العنوان: | Daily Oxygen/O3 Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise |
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| المؤلفون: | Maria Consiglia Trotta, Roberto Alfano, Marina Accardo, Margherita Luongo, Dario Siniscalco, Francesca Ferraraccio, Luigi Mascolo, Claudia Rossi, Rosa Maisto, C Di Filippo, Michele D'Amico |
| المصدر: | Oxidative Medicine and Cellular Longevity, Vol 2015 (2015) |
| بيانات النشر: | Hindawi Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Aging, medicine.medical_specialty, Article Subject, Muscle fatigue, Chemistry, lcsh:Cytology, Diastole, Hemodynamics, chemistry.chemical_element, Physical exercise, Cell Biology, General Medicine, Biochemistry, Oxygen, Surgery, Muscle hypertrophy, Blood pressure, Internal medicine, Heart rate, medicine, Cardiology, lcsh:QH573-671 |
| الوصف: | Rats receiving daily intraperitoneal administration of O2and running on a treadmill covered an average distance of 482.8 ± 21.8 m/week as calculated during 5-week observation. This distance was increased in rats receiving daily intraperitoneal administration of an oxygen/O3mixture at a dose of 100; 150; and 300 μg/kg with the maximum increase being +34.5% at 300 μg/kg and still present after stopping the administration of oxygen/O3. Oxygen/O3decreased the mean arterial blood pressure (−13%), the heart rate (−6%), the gastrocnemius and cardiac hypertrophy, and fibrosis and reduced by 49% the left ventricular mass and relative wall thickness measurements. Systolic and diastolic functions were improved in exercised oxygen/O3rats compared to O2rats. Oxygen/O3treatment led to higher MPI index starting from the dose of 150 μg/kg (p<0.05) and more effective (+14%) at a dose of 300 μg/kg oxygen/O3. Oxygen/O3dose-dependently increased the expression of the antioxidant enzymes Mn-SOD and GPx1 and of eNOS compared to the exercised O2rats. The same doses resulted in decrease of LDH levels, CPK, TnI, and nitrotyrosine concentration in the heart and gastrocnemius tissues, arguing a beneficial effect of the ozone molecule against the fatigue induced by a prolonged high intensity exercise. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1942-0994 1942-0900 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16b1dc6bddb8a2a060438915bcc8c2a https://doaj.org/article/e9d693b0ea294e13942774ca397dd9bf |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a16b1dc6bddb8a2a060438915bcc8c2a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 19420900 |
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