In vitro effects of thirty‐eight cardiac drugs on human serum paraoxonase
| العنوان: | In vitro effects of thirty‐eight cardiac drugs on human serum paraoxonase |
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| المؤلفون: | Onur Argan, Kubra Cikrikci, Harun Uslu, Nahit Gencer |
| المصدر: | Chemical Biology & Drug Design. 100:80-89 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Molecular Docking Simulation, Pharmacology, Aryldialkylphosphatase, Drug Discovery, Organic Chemistry, Humans, Molecular Medicine, Enzyme Inhibitors, Hydrophobic and Hydrophilic Interactions, Biochemistry |
| الوصف: | In this study, the effects of 38 commonly used cardiac drugs on the human paraoxonase (PON1) were investigated. PON1 was purified from human serum blood by ammonium sulfate precipitation (60%-80%) and hydrophobic interaction chromatography (Sepharose-4B~L-tyrosine~1-napthylamine gel). All of the cardiac drugs inhibited PON1 at the micro molar level. IC |
| تدمد: | 1747-0285 1747-0277 |
| DOI: | 10.1111/cbdd.14054 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b193b66fe72b7879b01bb3854e504b https://doi.org/10.1111/cbdd.14054 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a0b193b66fe72b7879b01bb3854e504b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17470285 17470277 |
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| DOI: | 10.1111/cbdd.14054 |