The modulatory role of high fat feeding on gastrointestinal signals in obesity
| العنوان: | The modulatory role of high fat feeding on gastrointestinal signals in obesity |
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| المؤلفون: | Mihai Covasa, Yassine Sakar, Frank Duca |
| المساهمون: | MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, INRA |
| المصدر: | Journal of Nutritional Biochemistry Journal of Nutritional Biochemistry, Elsevier, 2013, 24 (10), pp.1663-1677. ⟨10.1016/j.jnutbio.2013.05.005⟩ |
| بيانات النشر: | Elsevier BV, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | CD36 Antigens, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, GPR, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, REDUCES FOOD-INTAKE, Gut flora, Weight Gain, Biochemistry, Intestinal absorption, Receptors, G-Protein-Coupled, 0302 clinical medicine, Glucagon-Like Peptide 1, VAGAL AFFERENT NEURONS, PLASMA GHRELIN LEVELS, Adiposity, Cholecystokinin, 2. Zero hunger, 0303 health sciences, GLUCAGON-LIKE PEPTIDE-1, Nutrition and Dietetics, biology, Microbiota, Glucagon-like peptide-1, Ghrelin, PROTEIN-COUPLED RECEPTOR, Taste, 2-BOTTLE CHOICE TEST, medicine.symptom, Signal Transduction, DIET-INDUCED OBESITY, medicine.medical_specialty, OLIGOFRUCTOSE PROMOTES SATIETY, 030209 endocrinology & metabolism, Satiation, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, Peptide YY, Obesity, Molecular Biology, 030304 developmental biology, Diet adaptation, TOTAL PARENTERAL-NUTRITION, biology.organism_classification, medicine.disease, Dietary Fats, Gastrointestinal Tract, Endocrinology, Intestinal Absorption, HUMAN GUT MICROBIOTA, Gut peptides, Energy Intake, Weight gain |
| الوصف: | The gastrointestinal (GI) tract is a specialized sensory system that detects and responds to constant changes in nutrient- and bacterial-derived intestinal signals, thus contributing to controls of food intake. Chronic exposure to dietary fat causes morphological, physiological and metabolic changes leading to disruptions in the regulatory feeding pathways promoting more efficient fat absorption and utilization, blunted satiation signals and excess adiposity. Accumulating evidence demonstrates that impaired gastrointestinal signals following long-term high fat consumption are, at least partially, responsible for increased caloric intake. This review focuses on the role of dietary fat in modulating oral and post-oral chemosensory signaling elements responsible for lipid detection and responses, including changes in sensitivity to satiation signals, such as GLP-1, PYY and CCK and their impact on food intake and weight gain. Furthermore, the influence of the gut microbiota on mechanisms controlling energy regulation in the face of excessive fat exposure will be explored. The profound influence of dietary fats on altering complex regulatory feeding pathways can result in dysregulation of body weight and development of obesity, while restoration or manipulation of satiation signaling may prove an effective tool in prevention and treatment of obesity. (c) 2013 Elsevier Inc. All rights reserved. |
| تدمد: | 0955-2863 |
| DOI: | 10.1016/j.jnutbio.2013.05.005 |
| DOI: | 10.1016/j.jnutbio.2013.05.005⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0518124861ec3e10d8f557ff6b31e8a https://doi.org/10.1016/j.jnutbio.2013.05.005 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a0518124861ec3e10d8f557ff6b31e8a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09552863 |
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| DOI: | 10.1016/j.jnutbio.2013.05.005 |