Genetic Manipulation of Non-tuberculosis Mycobacteria
| العنوان: | Genetic Manipulation of Non-tuberculosis Mycobacteria |
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| المؤلفون: | Nyaradzai Mitchell Chimukuche, Monique J. Williams |
| المساهمون: | Department of Molecular and Cell Biology, Faculty of Science |
| المصدر: | Frontiers in Microbiology Frontiers in Microbiology, Vol 12 (2021) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Microbiology (medical), transposon mutagenesis, Genetic diversity, Tuberculosis, lcsh:QR1-502, Mutagenesis (molecular biology technique), homologous recombination, Computational biology, Review, Biology, medicine.disease, Genome, Microbiology, lcsh:Microbiology, recombineering, CRISPR/Cas, medicine, CRISPR, non-tuberculosis mycobacteria (NTMs), Large group, mutagenesis |
| الوصف: | Non-tuberculosis mycobacteria (NTMs) comprise a large group of organisms that are phenotypically diverse. Analysis of the growing number of completed NTM genomes has revealed both significant intra-genus genetic diversity, and a high percentage of predicted genes that appear to be unique to this group. Most NTMs have not been studied, however, the rise in NTM infections in several countries has prompted increasing interest in these organisms. Mycobacterial research has recently benefitted from the development of new genetic tools and a growing number of studies describing the genetic manipulation of NTMs have now been reported. In this review, we discuss the use of both site-specific and random mutagenesis tools in NTMs, highlighting the challenges that exist in applying these techniques to this diverse group of organisms. |
| وصف الملف: | application/pdf |
| تدمد: | 1664-302X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02fa7c3e605e93cead4a870f241f99f https://pubmed.ncbi.nlm.nih.gov/33679662 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a02fa7c3e605e93cead4a870f241f99f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1664302X |
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