Small dose of oral gastrografin for computed tomography-based image-guided brachytherapy in patients with uterine cervical cancer
| العنوان: | Small dose of oral gastrografin for computed tomography-based image-guided brachytherapy in patients with uterine cervical cancer |
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| المؤلفون: | Takafumi Toita, Joichi Heianna, Akihiro Nishie, Takuto Ogura, Hitoshi Maemoto, Yuka Kawakami, Wataru Kudaka, Yoichi Aoki, Takuro Ariga, Shota Takehara, Kazuki Ishikawa, Seiji Hashimoto |
| المصدر: | Journal of Radiation Research |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | cervical cancer, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Brachytherapy, Uterus, Contrast Media, Uterine Cervical Neoplasms, Computed tomography, computed tomography (CT), Oncology/Medicine, Oral administration, medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, Diatrizoate Meglumine, Cervical cancer, Radiation, medicine.diagnostic_test, business.industry, medicine.disease, Small intestine, Radiation therapy, image-guided brachytherapy (IGBT), gastrografin, medicine.anatomical_structure, AcademicSubjects/SCI00960, Female, AcademicSubjects/MED00870, Tomography, X-Ray Computed, Nuclear medicine, business |
| الوصف: | Oral administration of a water-soluble iodine contrast agent (gastrografin) was reported to assist in the appropriate contouring of the small intestine on computed tomography (CT)-based radiotherapy (RT) planning. The efficacy and optimal dose of gastrografin in CT-based image-guided brachytherapy (IGBT) for cervical cancer remain unknown. This study aimed to investigate the efficacy of pretreatment oral administration of gastrografin at a small dose of 50 ml in CT-based IGBT for cervical cancer. A total of 422 sessions in 137 patients who underwent CT-based IGBT with 50 ml of oral gastrografin (concentration, 3% or 4%) were analyzed. Preparation of gastrografin was judged as effective when the small intestine was contrast-enhanced at the area where the small intestine was in contact with the uterus/adnexa. About 287 out of 422 sessions (68%) were judged as effective with gastrografin preparation. The 135 ineffective sessions were considered as follows: (i) the contrast enhancement of the small intestine was not confirmed (n = 36), (ii) the small intestine was not in contact with the uterus/adnexa despite the confirmation of the contrast enhancement of the small intestine (n = 34), and (iii) gastrografin was absent in the small intestine at the area in contact with the uterus/adnexa, even when gastrografin was observed in the small intestine at the area not in contact with the uterus/adnexa (n = 65). In conclusion, pretreatment oral administration of a small dose gastrografin achieved moderate efficacy for accurate contouring of the small intestine close to the uterus/adnexa in CT-based IGBT for cervical cancer. |
| تدمد: | 1349-9157 0449-3060 |
| DOI: | 10.1093/jrr/rrab102 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb09d8ac05ef94d641dbe56677bd6f0 https://doi.org/10.1093/jrr/rrab102 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9eb09d8ac05ef94d641dbe56677bd6f0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13499157 04493060 |
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| DOI: | 10.1093/jrr/rrab102 |