Association of infections and venous thromboembolism in hospitalized children with nephrotic syndrome
| العنوان: | Association of infections and venous thromboembolism in hospitalized children with nephrotic syndrome |
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| المؤلفون: | Cheryl L. Tran, Michelle N. Rheault, Meredith Seamon, Bryce A. Kerlin, Shannon L. Carpenter, David T. Selewski, Chryso Katsoufis, Joel Hernandez, Jennifer L. Goldman, Prasad Devarajan, Nilka DeJesus-Gonzalez, Christopher Woll, Mahmoud Kallash, Pavel Geier, Tetyana L. Vasylyeva, Cassandra Formeck, William E. Smoyer, Rasheed Gbadegesin, Isa F. Ashoor, Ashley K. Sherman, Cynthia D’alessandri-Silva, Katarina Supe-Markovina |
| المصدر: | Pediatric Nephrology. 34:261-267 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Nephrology, medicine.medical_specialty, Nephrotic Syndrome, 030232 urology & nephrology, 030204 cardiovascular system & hematology, Logistic regression, Article, Pneumococcal Infections, law.invention, 03 medical and health sciences, 0302 clinical medicine, Focal segmental glomerulosclerosis, Risk Factors, law, Internal medicine, Prevalence, medicine, Humans, Minimal change disease, cardiovascular diseases, Child, Retrospective Studies, business.industry, Venous Thromboembolism, Length of Stay, medicine.disease, Intensive care unit, Intensive Care Units, Logistic Models, Streptococcus pneumoniae, Child, Preschool, North America, Pediatrics, Perinatology and Child Health, Cohort, Female, Complication, business, Nephrotic syndrome |
| الوصف: | BACKGROUND: Nephrotic syndrome (NS) results in hypercoagulability and increased risk of infection. Furthermore, infection increases the risk of venous thromboembolism (VTE). Our objective was to determine the prevalence of infection, VTE, and the associated outcomes among a cohort of hospitalized children with NS. METHODS: All children with NS admitted to 17 pediatric hospitals across North America from 2010 to 2012 were included. Prevalence of infection and VTE was determined. Wilcoxon rank-sum and logistic regression were performed. RESULTS: Seven-hundred thirty hospitalizations occurred among 370 children with NS. One-hundred forty-eight children (40%) had ≥ 1 infection (211 episodes) and 11 (3%) had VTE. Those with VTE had infection more frequently (p = 0.046) and were younger at NS diagnosis (3.0 vs. 4.0 years; p = 0.008). The most common infectious pathogen identified was Streptococcus pneumoniae. The median hospital length of stay for those with infection [10 vs 5 days (p < 0.0001)] or VTE [22 vs 6 days (p < 0.0001)] was longer than those without either complication. Of those with infection, 13% had an intensive care unit (ICU) stay compared with 3.3% of those without infection. Median ICU stay was 4 days in those with VTE compared to 0 days in those without (p < 0.001). By logistic regression, only the number of ICU days was associated with VTE (OR 1.074, 95% CI 1.013–1.138). CONCLUSIONS: Hospitalized children with NS have high rates of infection. Presence of VTE was associated with infection. Both were associated with longer hospitalizations and ICU stays. |
| تدمد: | 1432-198X 0931-041X |
| DOI: | 10.1007/s00467-018-4072-6 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8c617390d8e619dcdce38e7c371e3e https://doi.org/10.1007/s00467-018-4072-6 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9e8c617390d8e619dcdce38e7c371e3e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1432198X 0931041X |
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| DOI: | 10.1007/s00467-018-4072-6 |