Association of Diabetic Ketoacidosis and HbA1c at Onset with Year-Three HbA1c in Children and Adolescents with Type 1 Diabetes: Data from the International SWEET Registry
| العنوان: | Association of Diabetic Ketoacidosis and HbA1c at Onset with Year-Three HbA1c in Children and Adolescents with Type 1 Diabetes: Data from the International SWEET Registry |
|---|---|
| المؤلفون: | H. J. Veeze, Régis Coutant, Roque Cardona-Hernandez, Jae Hyun Kim, Romualdas Tomas Preiksa, Ilknur Arslanoglu, Craig Jefferies, Auste Pundziute Lyckå, Radka Savova, Barbara Piccini, Birgit Rami-Merhar, Sonia Toni, Anke Schwandt, Olga Kordonouri, Catarina Limbert, Sweet registry, Sladjana Todorovic, Erick Richmond |
| المساهمون: | [Belirlenecek] |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Pediatrics, medicine.medical_specialty, Youth, Glycated Hemoglobin A, Demographics, Diabetic ketoacidosis, endocrine system diseases, type 1 diabetes, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Diabetic Ketoacidosis, 03 medical and health sciences, 0302 clinical medicine, diabetic ketoacidosis, HDE END PED, children, Metabolic-Control, Diagnosis, Internal Medicine, Medicine, Humans, Hba(1C), 030212 general & internal medicine, Registries, Coma, Child, Glycated Hemoglobin, Type 1 diabetes, business.industry, Tracking, nutritional and metabolic diseases, Frequency, metabolic control, medicine.disease, Diabetes Mellitus, Type 1, Metabolic control analysis, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, business, Predictor |
| الوصف: | Piccini, Barbara/0000-0002-2684-8638; Kim, Jae Hyun/0000-0002-0203-7443; Jefferies, Craig/0000-0002-0541-6094; Schwandt, Anke/0000-0003-3041-0759 WOS: 000503343500001 PubMed: 31797499 Objective To establish whether diabetic ketoacidosis (DKA) or HbA1c at onset is associated with year-three HbA1c in children with type 1 diabetes (T1D). Methods Children with T1D from the SWEET registry, diagnosed = 12%]). To adjust for demographics, linear regression was applied with interaction terms for DKA and HbA1c at onset groups (adjusted means with 95% CI). Association between year-three HbA1c and both HbA1c and presentation at onset was analyzed (Vuong test). Results Among 1420 children (54% males; median age at onset 9.1 years [Q1;Q3: 5.8;12.2]), 6% of children experienced DKA with coma, 37% DKA without coma, and 57% no DKA. Year-three HbA1c was lower in the low compared to high HbA1c at onset group, both in the DKA without coma (7.1% [6.8;7.4] vs 7.6% [7.5;7.8], P = .03) and in the no DKA group (7.4% [7.2;7.5] vs 7.8% [7.6;7.9], P = .01), without differences between low and medium HbA1c at onset groups. Year-three HbA1c did not differ among HbA1c at onset groups in the DKA with coma group. HbA1c at onset as an explanatory variable was more closely associated with year-three HbA1c compared to presentation at onset groups (P = .02). Conclusions Year-three HbA1c is more closely related to HbA1c than to DKA at onset; earlier hyperglycemia detection might be crucial to improving year-three HbA1c. Insulet; Sanofi; Medtronic EuropeMedtronic; Lilly Diabetes Excellence Centre; DexCom Inc.; AbbottAbbott Laboratories; Boehringer-IngelheimBoehringer Ingelheim Insulet; Sanofi; Medtronic Europe; Lilly Diabetes Excellence Centre; DexCom Inc.; Boehringer-Ingelheim; Abbott |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7bf4985e3c27c54deb11ca61773eac https://hdl.handle.net/10400.17/3679 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9d7bf4985e3c27c54deb11ca61773eac |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |