Identification and characterization of latency-associated peptide-expressing γδ T cells
| العنوان: | Identification and characterization of latency-associated peptide-expressing γδ T cells |
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| المؤلفون: | Andre Pires da Cunha, Stephen Rubino, Hanane M’Hamdi, Galina Gabriely, Ana Maria Caetano Faria, Howard L. Weiner, Tyler Vandeventer, Rafael M. Rezende, Jellert T. Gaublomme, Shirong Liu, Ron Cialic, Natalia Pinheiro-Rosa, Nathalie Pochet, Rafael Pires Oliveira, Chantal Kuhn, James A. Kozubek, Nikolaus D. Obholzer |
| المصدر: | Nature Communications |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | General Physics and Astronomy, T-Lymphocytes, Regulatory, Mice, Peyer's Patches, 0302 clinical medicine, Intestinal mucosa, Animals, Congenic, T-Lymphocyte Subsets, Interferon gamma, Intestinal Mucosa, 0303 health sciences, Multidisciplinary, medicine.diagnostic_test, Reverse Transcriptase Polymerase Chain Reaction, digestive, oral, and skin physiology, FOXP3, Forkhead Transcription Factors, Receptors, Antigen, T-Cell, gamma-delta, Colitis, Flow Cytometry, 3. Good health, Cell biology, medicine.anatomical_structure, Cytokines, medicine.drug, Adult, T cell, Antigen presentation, Receptors, Antigen, T-Cell, Antigen-Presenting Cells, Biology, In Vitro Techniques, Real-Time Polymerase Chain Reaction, General Biochemistry, Genetics and Molecular Biology, Article, Flow cytometry, Transforming Growth Factor beta1, 03 medical and health sciences, Interferon-gamma, Antigen, medicine, Animals, Humans, Antigen-presenting cell, 030304 developmental biology, Activating Transcription Factor 3, General Chemistry, Disease Models, Animal, Immunology, Leukocytes, Mononuclear, human activities, 030215 immunology |
| الوصف: | γδ T cells are a subset of lymphocytes specialized in protecting the host against pathogens and tumours. Here we describe a subset of regulatory γδ T cells that express the latency-associated peptide (LAP), a membrane-bound TGF-β1. Thymic CD27+IFN-γ+CCR9+α4β7+TCRγδ+ cells migrate to the periphery, particularly to Peyer's patches and small intestine lamina propria, where they upregulate LAP, downregulate IFN-γ via ATF-3 expression and acquire a regulatory phenotype. TCRγδ+LAP+ cells express antigen presentation molecules and function as antigen presenting cells that induce CD4+Foxp3+ regulatory T cells, although TCRγδ+LAP+ cells do not themselves express Foxp3. Identification of TCRγδ+LAP+ regulatory cells provides an avenue for understanding immune regulation and biologic processes linked to intestinal function and disease. Latency-associated peptide (LAP) is a membrane-bound form of TGF-β1. Here the authors show that LAP marks a subset of regulatory γδ T cells with innate gut-homing properties, which present antigen and induce CD4+ Foxp3+ in Peyer's patches and lamina propria. |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d562f461b4c7d718526e078a40f8e5d https://pubmed.ncbi.nlm.nih.gov/26644347 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9d562f461b4c7d718526e078a40f8e5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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