Experimental animal models of post-traumatic osteoarthritis of the knee
| العنوان: | Experimental animal models of post-traumatic osteoarthritis of the knee |
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| المؤلفون: | Kristine M. Fischenich, Tammy L. Haut Donahue, Gerardo E. Narez |
| المصدر: | Orthopedic Reviews, Vol 12, Iss 2 (2020) Orthopedic Reviews |
| بيانات النشر: | Open Medical Publishing, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Orthopedic surgery, medicine.medical_specialty, ACLT, business.industry, Anterior cruciate ligament, Post-traumatic osteoarthritis, Post traumatic osteoarthritis, review, PTOA, Experimental Animal Models, Articular cartilage, Osteoarthritis, Meniscus (anatomy), Knee Joint, medicine.disease, animal models, Tissue Degeneration, medicine.anatomical_structure, Physical medicine and rehabilitation, medicine, Orthopedics and Sports Medicine, business, RD701-811 |
| الوصف: | Due to the complex and dynamic nature of osteoarthritis (OA) and post-traumatic osteoarthritis (PTOA), animal models have been used to investigate the progression and pathogenesis of the disease. Researchers have used different experimental models to study OA and PTOA. With an emphasis on the knee joint, this review will compare and contrast the existing body of knowledge from anterior cruciate ligament transection models, meniscectomy models, combination models, as well as impact models in large animals to see how tissues respond to these different approaches to induce experimental OA and PTOA. The tissues discussed will include articular cartilage and the meniscus, with a focus on morphological, mechanical and histological assessments. The goal of this review is to demonstrate the progressive nature of OA by indicating the strong correlation between progressive tissue degeneration, change of mechanical properties, and loss of biochemical integrity and to highlight key differences between the most commonly used experimental animal models. |
| اللغة: | English |
| تدمد: | 2035-8164 2035-8237 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c771b6e5c5468f6dd3eb6b8587f814a https://www.pagepress.org/journals/index.php/or/article/view/8448 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9c771b6e5c5468f6dd3eb6b8587f814a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20358164 20358237 |
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