Late effects of adjuvant chemotherapy for adult onset non-CNS cancer; cognitive impairment, brain structure and risk of dementia
| العنوان: | Late effects of adjuvant chemotherapy for adult onset non-CNS cancer; cognitive impairment, brain structure and risk of dementia |
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| المؤلفون: | Willem Boogerd, Monique M.B. Breteler, Vincent Koppelmans, Sanne B. Schagen, Caroline Seynaeve |
| المساهمون: | Epidemiology, Medical Oncology |
| المصدر: | Critical Reviews in Oncology/Hematology, 88(1), 87-101. Elsevier Ireland Ltd Critical reviews in oncology, hematology 88(1), 87-101 (2013). doi:10.1016/j.critrevonc.2013.04.002 |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Oncology, drug therapy [Neoplasms], medicine.medical_treatment, Neuropsychological Tests, adverse effects [Antineoplastic Combined Chemotherapy Protocols], pathology [Brain], Neoplasms, Antineoplastic Combined Chemotherapy Protocols, therapeutic use [Antineoplastic Agents], Survivors, complications [Neoplasms], Mental Disorders, Neuropsychology, Age Factors, Brain, Cognition, Hematology, therapeutic use [Antineoplastic Combined Chemotherapy Protocols], Chemotherapy, Adjuvant, drug effects [Brain], etiology [Mental Disorders], Risk, medicine.medical_specialty, Brain Structure and Function, Antineoplastic Agents, Neuroimaging, diagnosis [Mental Disorders], adverse effects [Antineoplastic Agents], Breast cancer, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Dementia, Humans, ddc:610, Psychiatry, diagnosis [Cognition Disorders], Chemotherapy, business.industry, etiology [Cognition Disorders], Cancer, medicine.disease, diagnosis [Dementia], adverse effects [Chemotherapy, Adjuvant], etiology [Dementia], business, Cognition Disorders |
| الوصف: | Few studies have investigated the late (i.e. >= 5 years post-treatment) effects of chemotherapy for non-central nervous system (non-CNS) cancer on the brain. Here we discuss the studies that have investigated the late effects of adjuvant chemotherapy for non-CNS cancer on cognitive function (n = 6); brain structure and function (it = 5); and incidence of dementia (n = 4). The neuropsychological studies showed long-term adverse cognitive problems in chemotherapy-exposed breast cancer survivors. This is in line with results from neuroimaging studies that report long-term brain structural alterations after chemotherapy. The studies exploring the association between chemotherapy and the incidence of dementia were contradictive and showed no clear relationship between the two phenomena. Although several methodological issues limit the validity and interpretation of some of the results of these studies, they suggest that chemotherapy is associated with subtle, yet long-lasting cognitive deficits, possibly related to brain structural and functional differences, but as yet not with an increased risk of dementia. (C) 2013 Elsevier Ireland Ltd. All rights reserved. |
| تدمد: | 1879-0461 1040-8428 |
| DOI: | 10.1016/j.critrevonc.2013.04.002 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3271f4813761d405ce7689bfe2d115 https://pubmed.ncbi.nlm.nih.gov/23768778 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9c3271f4813761d405ce7689bfe2d115 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18790461 10408428 |
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| DOI: | 10.1016/j.critrevonc.2013.04.002 |