TEMPy2: a Python library with improved 3D electron microscopy density-fitting and validation workflows
| العنوان: | TEMPy2: a Python library with improved 3D electron microscopy density-fitting and validation workflows |
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| المؤلفون: | Agnel Praveen Joseph, Sony Malhotra, Harpal Sahota, Aaron Sweeney, Daven Vasishtan, Tristan Cragnolini, Maya Topf |
| المصدر: | Acta Crystallographica. Section D, Structural Biology |
| بيانات النشر: | International Union of Crystallography, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Models, Molecular, 3d electron microscopy, Macromolecular Substances, Computer science, Molecular Conformation, Model fitting, bcs, Workflow, Computational science, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Image Processing, Computer-Assisted, Three dimensional electron microscopy, macromolecular complexes, Biological sciences, 030304 developmental biology, computer.programming_language, validation, 0303 health sciences, model assessment, Cryoelectron Microscopy, TEMPy2, Python (programming language), fitting scores, Macromolecular Complexes, three-dimensional electron microscopy, Density fitting, model fitting, Ccp4, computer, Software, 030217 neurology & neurosurgery |
| الوصف: | TEMPy2, an update of the TEMPy package to process, optimize and assess cryo-EM maps and the structures fitted to them, is presented. Structural determination of molecular complexes by cryo-EM requires large, often complex processing of the image data that are initially obtained. Here, TEMPy2, an update of the TEMPy package to process, optimize and assess cryo-EM maps and the structures fitted to them, is described. New optimization routines, comprehensive automated checks and workflows to perform these tasks are described. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2059-7983 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf3b65f4a5f3eafbec9bc2de09e10ae https://eprints.bbk.ac.uk/id/eprint/42601/1/42601.pdf |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9bf3b65f4a5f3eafbec9bc2de09e10ae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20597983 |
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