Immune-enhancement effects of tuna cooking drip and its enzymatic hydrolysate in Balb/c mice
| العنوان: | Immune-enhancement effects of tuna cooking drip and its enzymatic hydrolysate in Balb/c mice |
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| المؤلفون: | Dong-Hyun Ahn, Min-Ji Kim, Koth-Bong-Woo-Ri Kim, Hee-Sup Nam, Eui-Hong Byun, Nak-Yun Sung |
| المصدر: | Food Science and Biotechnology. 27:131-137 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, T cell, Spleen, Pharmacology, Applied Microbiology and Biotechnology, Article, Hydrolysate, BALB/c, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Splenocyte, biology, Chemistry, food and beverages, biology.organism_classification, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, cardiovascular system, biology.protein, Antibody, Tuna, Food Science, Biotechnology |
| الوصف: | Tuna cooking drip (TCD) is a protein rich by-product of canned tuna processing that is typically discarded. In this study, the immune-enhancing activities of TCD and its enzymatic hydrolysate (EH-TCD) were investigated by intraperitoneally administering Balb/c male mice with TCD and EH-TCD for 2 weeks. This administration resulted in an increase in the weight of the spleen and thymus (200-800 mg/kg) and enhanced the proliferation rates of splenocytes (200-800 mg/kg). TCD and EH-TCD significantly increased the production of immunostimulatory cytokines (interleukin-10 and interleukin-2). In addition, TCD and EH-TCD increased serum IgG1 and IgG2a levels in a concentration-dependent manner. Particularly, EH-TCD had a greater immune-enhancing effect than TCD. These results suggest that TCD and EH-TCD exert immune-enhancing effects through an IgG antibody response and T cell activation, and EH-TCD can be used as an immunostimulatory agent. |
| تدمد: | 2092-6456 1226-7708 |
| DOI: | 10.1007/s10068-017-0278-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9d2ffd9b3bb6602078f6a86a990051 https://doi.org/10.1007/s10068-017-0278-9 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9b9d2ffd9b3bb6602078f6a86a990051 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20926456 12267708 |
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| DOI: | 10.1007/s10068-017-0278-9 |