Cytomegalovirus immunoevasin reveals the physiological role of 'missing self' recognition in natural killer cell dependent virus control in vivo
| العنوان: | Cytomegalovirus immunoevasin reveals the physiological role of 'missing self' recognition in natural killer cell dependent virus control in vivo |
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| المؤلفون: | Astrid Krmpotić, Maja Mitrović, Marina Babić, Michal Pyzik, Lewis L. Lanier, Silvia M. Vidal, Biljana Zafirova, Višnja Butorac, Stipan Jonjić |
| المصدر: | The Journal of Experimental Medicine Volume 207 Issue 12 The Journal of experimental medicine, vol 207, iss 12 |
| بيانات النشر: | The Rockefeller University Press, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Cytotoxicity, Immunologic, Muromegalovirus, Cytotoxicity, Inbred Strains, NK cells, Lymphocyte Activation, Medical and Health Sciences, Interleukin 21, Mice, 0302 clinical medicine, Immunologic, Immunology and Allergy, Killer Cells, 0303 health sciences, Membrane Glycoproteins, biology, 3. Good health, Cell biology, Killer Cells, Natural, Infectious Diseases, medicine.anatomical_structure, NK Cell Lectin-Like Receptor Subfamily K, MCMV, MHC-I, Ly49 receptors, Natural, Infection, BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti, NK Cell Lectin-Like Receptor Subfamily A, 1.1 Normal biological development and functioning, Antigen presentation, Immunology, Mice, Inbred Strains, Major histocompatibility complex, Article, Natural killer cell, Vaccine Related, 03 medical and health sciences, Viral Proteins, Underpinning research, Biodefense, MHC class I, medicine, Animals, 030304 developmental biology, Glycoproteins, Immune Evasion, Lymphokine-activated killer cell, Prevention, BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences, H-2 Antigens, Virology, Emerging Infectious Diseases, biology.protein, Carrier Proteins, CD8, 030215 immunology |
| الوصف: | Natural killer cell recognition of “missing self” contributes meaningfully to control of mouse cytomegalovirus infection in vivo. Cytomegaloviruses (CMVs) are renowned for interfering with the immune system of their hosts. To sidestep antigen presentation and destruction by CD8+ T cells, these viruses reduce expression of major histocompatibility complex class I (MHC I) molecules. However, this process sensitizes the virus-infected cells to natural killer (NK) cell–mediated killing via the “missing self” axis. Mouse cytomegalovirus (MCMV) uses m152 and m06 encoded proteins to inhibit surface expression of MHC I molecules. In addition, it encodes another protein, m04, which forms complexes with MHC I and escorts them to the cell surface. This mechanism is believed to prevent NK cell activation and killing by restoring the “self” signature and allowing the engagement of inhibitory Ly49 receptors on NK cells. Here we show that MCMV lacking m04 was attenuated in an NK cell– and MHC I–dependent manner. NK cell–mediated control of the infection was dependent on the presence of NK cell subsets expressing different inhibitory Ly49 receptors. In addition to providing evidence for immunoevasion strategies used by CMVs to avoid NK cell control via the missing-self pathway, our study is the first to demonstrate that missing self–dependent NK cell activation is biologically relevant in the protection against viral infection in vivo. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.20100921 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3d3f4a2f1a5c8a1fca287e55230e07 http://europepmc.org/articles/PMC2989764 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9b3d3f4a2f1a5c8a1fca287e55230e07 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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| DOI: | 10.1084/jem.20100921 |