Additional Value of Intra-Aneurysmal Hemodynamics in Discriminating Ruptured versus Unruptured Intracranial Aneurysms
| العنوان: | Additional Value of Intra-Aneurysmal Hemodynamics in Discriminating Ruptured versus Unruptured Intracranial Aneurysms |
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| المؤلفون: | R. van den Berg, Aart J. Nederveen, Gabriel J.E. Rinkel, P. van Ooij, E. VanBavel, Charles B. L. M. Majoie, Henk A. Marquering, William P. Vandertop, J.J. Schneiders, Dagmar Verbaan, M. J. B. M. Pourquie |
| المساهمون: | Amsterdam Cardiovascular Sciences, Amsterdam Neuroscience, Radiology and Nuclear Medicine, Biomedical Engineering and Physics, Neurosurgery, Internal medicine, CCA - Cancer biology and immunology, CCA - Target Discovery & Preclinial Therapy Development |
| المصدر: | AJNR. American journal of neuroradiology, 36(10), 1920-1926. American Society of Neuroradiology Schneiders, J J, Marquering, H A, van Ooij, P, van den Berg, R, Nederveen, A J, Verbaan, D, Vandertop, W P, Pourquie, M, Rinkel, G J E, vanBavel, E & Majoie, C B L M 2015, ' Additional Value of Intra-Aneurysmal Hemodynamics in Discriminating Ruptured versus Unruptured Intracranial Aneurysms ', American Journal of Neuroradiology, vol. 36, no. 10, pp. 1920-6 . https://doi.org/10.3174/ajnr.A4397 AJNR Am J Neuroradiol American Journal of Neuroradiology, 36(10), 1920. American Society of Neuroradiology American Journal of Neuroradiology, 36(10), 1920-6. American Society of Neuroradiology |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Patient-Specific Modeling, Cerebral arteries, Hemodynamics, Hemodynamics/physiology, Aneurysm, Ruptured, Magnetic Resonance Imaging/methods, Intracranial Aneurysm/diagnosis, Risk Factors, Diagnosis, CFD=computational fluid dynamics, Non-U.S. Gov't, Univariate analysis, medicine.diagnostic_test, Interventional, Research Support, Non-U.S. Gov't, Middle Aged, Magnetic Resonance Imaging, Radiology Nuclear Medicine and imaging, Predictive value of tests, Cerebral Angiography/methods, Female, Radiology, Blood Flow Velocity, Cerebral angiography, Adult, medicine.medical_specialty, 3DRA=3D rotational angiography, Ruptured/diagnosis, Clinical Neurology, Aneurysm, Ruptured/diagnosis, Research Support, Diagnosis, Differential, Aneurysm, Predictive Value of Tests, medicine.artery, medicine, Journal Article, Humans, Radiology, Nuclear Medicine and imaging, Posterior communicating artery, cardiovascular diseases, Aged, business.industry, Blood Flow Velocity/physiology, Magnetic resonance imaging, Intracranial Aneurysm, PC=phase-contrast, medicine.disease, Cerebral Angiography, Cross-Sectional Studies, Differential, Hydrodynamics, Neurology (clinical), business |
| الوصف: | BACKGROUND AND PURPOSE: Hemodynamics are thought to play an important role in the rupture of intracranial aneurysms. We tested whether hemodynamics, determined from computational fluid dynamics models, have additional value in discriminating ruptured and unruptured aneurysms. Such discriminative power could provide better prediction models for rupture.MATERIALS AND METHODS: A cross-sectional study was performed on patients eligible for endovascular treatment, including 55 ruptured and 62 unruptured aneurysms. Association with rupture status was tested for location, aneurysm type, and 4 geometric and 10 hemodynamic parameters. Patient-specific spatiotemporal velocities measured with phase-contrast MR imaging were used as inflow conditions for computational fluid dynamics. To assess the additional value of hemodynamic parameters, we performed 1 univariate and 2 multivariate analyses: 1 traditional model including only location and geometry and 1 advanced model that included patient-specific hemodynamic parameters.RESULTS: In the univariate analysis, high-risk locations (anterior cerebral arteries, posterior communicating artery, and posterior circulation), daughter sacs, unstable inflow jets, impingements at the aneurysm body, and unstable complex flow patterns were significantly present more often in ruptured aneurysms. In both multivariate analyses, only the high-risk location (OR, 3.92; 95% CI, 1.77-8.68) and the presence of daughter sacs (OR, 2.79; 95% CI, 1.25-6.25) remained as significant independent determinants.CONCLUSIONS: In this study population of patients eligible for endovascular treatment, we found no independent additional value of aneurysmal hemodynamics in discriminating rupture status, despite high univariate associations. Only traditional parameters (high-risk location and the presence of daughter sacs) were independently associated with ruptured aneurysms. |
| وصف الملف: | image/pdf |
| اللغة: | English |
| تدمد: | 0195-6108 |
| DOI: | 10.3174/ajnr.A4397 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2ad9530d5863fc44ca4b86037dfbe2 https://pure.amc.nl/en/publications/additional-value-of-intraaneurysmal-hemodynamics-in-discriminating-ruptured-versus-unruptured-intracranial-aneurysms(f567f39d-fe36-4d67-a97b-ee27cea187af).html |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9b2ad9530d5863fc44ca4b86037dfbe2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01956108 |
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| DOI: | 10.3174/ajnr.A4397 |