Effect of Genetic Variants Related to Lipid Metabolism as Risk Factors for Cholelithiasis After Bariatric Surgery in Brazilian Population
| العنوان: | Effect of Genetic Variants Related to Lipid Metabolism as Risk Factors for Cholelithiasis After Bariatric Surgery in Brazilian Population |
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| المؤلفون: | Greiciane Maria da Silva Florim, Carla Barbosa Nonino, Gilberto B. Brito, Anielli Pinheiro, Camila M. Mazeti, Marina G. Moschetta, Dorotéia Rossi Silva Souza, Sidney Pinheiro-Júnior, Sergio L. A. Brienze, Marcelo Arruda Nakazone, Antônio Carlos Brandão, Michele Lima Gregório, Marcela Augusta de Souza Pinhel, Gisele S. Amorim |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, Apolipoprotein E, medicine.medical_specialty, Adolescent, Genotype, ESTUDOS DE CASOS E CONTROLES, Endocrinology, Diabetes and Metabolism, Gastric Bypass, Body Mass Index, Apolipoproteins E, Young Adult, Gene Frequency, Cholelithiasis, Risk Factors, Internal medicine, Cholesterylester transfer protein, medicine, Humans, Genetic Predisposition to Disease, Allele frequency, Aged, Nutrition and Dietetics, biology, business.industry, Case-control study, Lipid metabolism, Middle Aged, Cholesterol Ester Transfer Proteins, Obesity, Morbid, Surgery, Logistic Models, Endocrinology, Case-Control Studies, biology.protein, Female, lipids (amino acids, peptides, and proteins), business, Body mass index, Brazil, Polymorphism, Restriction Fragment Length, Follow-Up Studies |
| الوصف: | The manifestation of cholelithiasis after bariatric surgery may depend on genetic factors related to lipid metabolism, including apolipoprotein E (APOE) and cholesteryl ester transfer protein (CETP) gene polymorphisms.We investigated the association between APOE HhaI and CETP TaqIB polymorphisms [PCR-RFLP] and occurrence of cholelithiasis over up to 8 months of follow-up after gastroplasty to Roux-en-Y gastric bypass in 220 patients distributed in Group 1 (G1) 114 with cholelithiasis postoperatively and Group 2 (G2) 106 without cholelithiasis, including biochemical and anthropometric profiles analyses.In our series, the allelic and genotypic distributions of CETP TaqIB and APOE HhaI polymorphisms were similar in both groups (P 0.05). The subgroup analysis evidenced that 54% of the patients from G1, APOE*4 allele carriers compared with APOE*3/3 carriers, presented altered low-density lipoprotein cholesterol (LDL cholesterol) serum levels (P = 0.022) before bariatric surgery. The B1 allele for CETP was associated to more quickly elevation of HDL cholesterol levels just in individuals without cholelitiasis (P 0.0001). The multivariate logistic regression analysis demonstrates correlation between APOE*4 allele, higher total cholesterol (TC) serum levels and prediposition to cholelitiasis in preoperative period. However, the presence of postoperative cholelithiasis was not associated with altered lipid profile.The CETP TaqIB and APOE HhaI polymorphisms do not seem to have association with gallstones in the late postoperative bariatric surgery, considering that these genetic variants do not differ subgroups of patients who are eligible to routine prophylactic cholecystectomy, at least in Brazilian population. |
| تدمد: | 1708-0428 0960-8923 |
| DOI: | 10.1007/s11695-012-0590-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af97752bbf458a9829dbbe46ccd3b86 https://doi.org/10.1007/s11695-012-0590-7 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9af97752bbf458a9829dbbe46ccd3b86 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17080428 09608923 |
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| DOI: | 10.1007/s11695-012-0590-7 |