4,4'‑bond secalonic acid D targets SP cells and inhibits metastasis in hepatocellular carcinoma
| العنوان: | 4,4'‑bond secalonic acid D targets SP cells and inhibits metastasis in hepatocellular carcinoma |
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| المؤلفون: | Ya‑Ping Li, Miao‑Miao Cheng, Li Chen, Qin‑Ying Liu, Qiu‑Hong Zheng, Shao‑Feng Lin |
| المصدر: | Molecular Medicine Reports. |
| بيانات النشر: | Spandidos Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cancer Research, Carcinoma, Hepatocellular, Lung Neoplasms, Xanthones, Transplantation, Heterologous, Cell, Biochemistry, Metastasis, Mice, Side population, Cell Movement, Cancer stem cell, Cell Line, Tumor, Genetics, medicine, ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Humans, Side-Population Cells, Molecular Biology, Cell Proliferation, Tissue Inhibitor of Metalloproteinase-1, Oncogene, Chemistry, Liver Neoplasms, Penicillium, Cancer, medicine.disease, medicine.anatomical_structure, Matrix Metalloproteinase 9, Oncology, Cell culture, Cancer research, Molecular Medicine, Female, Liver cancer |
| الوصف: | The existence of cancer stem cells (CSCs) is considered to be the main reason for chemoresistance, metastasis and the ultimate failure of treatment in hepatocellular carcinoma (HCC). However, there are a few chemical agents that may inhibit CSCs. The present study identified that 4,4'‑bond secalonic acid D (4,4'‑SAD), a compound isolated from the marine‑derived fungus Penicillium oxalicum, inhibited the growth of side population (SP) cells isolated from human liver cancer cell lines PLC/PRF/5 and HuH‑7 by attenuating the expression of ATP‑binding cassette superfamily G member 2. Furthermore, the results of wound healing, Transwell, western blotting and reverse transcription‑quantitative PCR assays demonstrated that 4,4'‑SAD suppressed the invasion and migration of SP cells by downregulating matrix metallopeptidase 9 (MMP‑9) and upregulating the antagonist tissue inhibitor of metalloproteinases 1 in vitro. Moreover, in vivo study results found that 4,4'‑SAD had anti‑lung metastasis efficacy via the decrease of MMP‑9 expression in the H22 HCC model of Kunming mice. Therefore, the present study identified the potential of 4,4'‑SAD as a promising candidate for the treatment of advanced liver cancer. |
| تدمد: | 1791-3004 1791-2997 |
| DOI: | 10.3892/mmr.2020.11055 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9d771fbe33dbc1c961700a577ae6e9 https://doi.org/10.3892/mmr.2020.11055 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9a9d771fbe33dbc1c961700a577ae6e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17913004 17912997 |
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| DOI: | 10.3892/mmr.2020.11055 |