التفاصيل البيبلوغرافية
| العنوان: |
Dynamic 3D tissue architecture directs BMP morphogen signaling during Drosophila wing morphogenesis |
| المؤلفون: |
Yunxian Huang, Yukitaka Ishimoto, Daniel Toddie-Moore, Osamu Shimmi, Stephanie Nix, Jinghua Gui, Kikushima K, Kracklauer M |
| بيانات النشر: |
Cold Spring Harbor Laboratory, 2018. |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
0303 health sciences, Wing, animal structures, Decapentaplegic, Cell growth, Growth factor, medicine.medical_treatment, Morphogenesis, Biology, Bone morphogenetic protein, Cell biology, 03 medical and health sciences, 0302 clinical medicine, medicine, Signal transduction, 030217 neurology & neurosurgery, 030304 developmental biology, Morphogen |
| الوصف: |
SummaryAt the level of organ formation, tissue morphogenesis drives developmental processes in animals, often involving the rearrangement of two-dimensional (2D) structures into more complex three-dimensional (3D) tissues. These processes can be directed by growth factor signaling pathways. However, little is known about how such morphological changes affect the spatiotemporal distribution of growth factor signaling. Here, using theDrosophilapupal wing, we address how Decapentaplegic (Dpp) / Bone Morphogenetic Protein (BMP) signaling and 3D wing morphogenesis are coupled. Dpp, expressed in the longitudinal veins (LVs) of the pupal wing, initially diffuses laterally during the inflation stage to regulate cell proliferation. Dpp localization is then refined to the LVs within each epithelial plane, but with active interplanar signaling for vein patterning, as the two epithelia appose. Our data further suggest that the 3D architecture of the wing epithelia directs the spatial distribution of BMP signaling, revealing how 3D morphogenesis is an emergent property of the interactions between extracellular signaling and tissue shape changes. |
| اللغة: |
English |
| DOI: |
10.1101/411009 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a900e8259b65662f98ba29182f39f6c |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....9a900e8259b65662f98ba29182f39f6c |
| قاعدة البيانات: |
OpenAIRE |