التفاصيل البيبلوغرافية
العنوان:
Comparative effects of a contraceptive vaginal ring delivering a nonandrogenic progestin and continuous ethinyl estradiol and a combined oral contraceptive containing levonorgestrel on hemostasis variables
المؤلفون:
Mandana Rad , Irving Sivin , Cornelis Kluft , Regine Sitruk-Ware , Joël Ménard , Marieke L. de Kam , Piet Meijer , Jacobus Burggraaf
المساهمون:
TNO Kwaliteit van Leven
المصدر:
American Journal of Obstetrics and Gynecology, 1, 195, 72-77
سنة النشر:
2006
مصطلحات موضوعية:
Ethinyl Estradiol-Norgestrel Combination , Biomedical Research , Ethinyl Estradiol , Sex hormone-binding globulin , partial thromboplastin time , Sex Hormone-Binding Globulin , Contraceptive Agents, Female , Levonorgestrel , education.field_of_study , biology , Fibrinolysis , drug effect , Obstetrics and Gynecology , Vaginal ring , Blood Coagulation Factors , Contraceptives, Oral, Combined , blood clotting factor 7 , contraception , ethinylestradiol , Female , Immunoradiometric Assay , protein S , Norprogesterones , medicine.drug , Venous thromboembolism , Adult , medicine.medical_specialty , analysis of variance , Adolescent , medicine.drug_class , Contraceptive vaginal ring , Population , ethinylestradiol plus norgestrel , elcometrine , Ethinylestradiol , Norgestrel , Nestorone , medicine , oral contraceptive agent , Humans , education , Biology , Activated Protein C Resistance , Gynecology , Coagulation , Oral contraceptives , levonorgestrel , vagina ring , business.industry , Contraceptive Devices, Female , Estrogens , Plasminogen , confidence interval , Estrogen , biology.protein , hemostasis , gestagen , vaginal delivery , business , Progestin , Protein C
الوصف:
Objective: This study aimed to compare the effects on hemostasis variables of a contraceptive vaginal ring with those of an oral contraceptive. Study design: Twenty-three and 22 healthy premenopausal women were randomized to the contraceptive vaginal ring (150 μg Nestorone and 15 μg ethinyl estradiol) or Stediril 30 during 3 cycles. Analysis of covariance was performed with baseline values as covariate. Results: The contraceptive vaginal ring changed most hemostasis variables similarly but raised (95% confidence intervals of percent treatment differences) Factor VIIt (28% to 49%), extrinsic activated protein C resistance (14% to 65%), and sex hormone-binding globulin (117% to 210%) and lowered Protein S (-32% to -16%) and the global activated partial thromboplastin time-based activated protein C resistance (-12% to -2%) more than the oral contraceptive. Conclusion: The contraceptive vaginal ring affected some measured hemostasis variables and sex hormone-binding globulin differently from the oral contraceptive, most likely because of difference in androgenicity of the progestins. The results suggest that the contraindications for oral contraceptive use would also apply to the tested contraceptive vaginal ring. © 2006 Mosby, Inc. All rights reserved. Chemicals / CAS: blood clotting factor 7, 9001-25-6; elcometrine, 7759-35-5; ethinylestradiol plus norgestrel, 8056-51-7; ethinylestradiol, 57-63-6; levonorgestrel, 797-63-7; Blood Coagulation Factors; Contraceptive Agents, Female; Contraceptives, Oral, Combined; Estrogens; Ethinyl Estradiol, 57-63-6; Ethinyl Estradiol-Norgestrel Combination, 8056-51-7; Norprogesterones; Plasminogen, 9001-91-6; Protein C; Sex Hormone-Binding Globulin; ST 1435, 7759-35-5
اللغة:
English
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6df560c11e7814c535e3f6a9e84ed3 http://resolver.tudelft.nl/uuid:94831182-47a5-4d64-961d-be38855d18a4
Rights:
OPEN
رقم الانضمام:
edsair.doi.dedup.....9a6df560c11e7814c535e3f6a9e84ed3
قاعدة البيانات:
OpenAIRE