Bio‐therapeutics from human milk: prospects and perspectives
| العنوان: | Bio‐therapeutics from human milk: prospects and perspectives |
|---|---|
| المؤلفون: | Harsh Panwar, Kumar Siddharth Singh, Amarjit Singh, Niharika Singh, Brij Pal Singh, Namita Rokana, Jaspreet Kaur |
| المصدر: | Journal of Applied Microbiology. 131:2669-2687 |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Functional role, Oligosaccharides, Biology, Applied Microbiology and Biotechnology, 03 medical and health sciences, Human health, fluids and secretions, Immune system, Animals, Humans, Immune Regulators, Clinical efficacy, Microbiome, 030304 developmental biology, 0303 health sciences, Milk, Human, 030306 microbiology, business.industry, Microbiota, Probiotics, Infant, food and beverages, General Medicine, Biotechnology, Milk, Prebiotics, business |
| الوصف: | Human milk is elixir for neonates and is a rich source of nutrients and beneficial microbiota required for infant growth and development. Its benefits prompted research into probing the milk components and their use as prophylactic or therapeutic agents. Culture-independent estimation of milk microbiome and high-resolution identification of milk components provide information, but a holistic purview of these research domains is lacking. Here, we review the current research on bio-therapeutic components of milk and simplified future directions for its efficient usage. Publicly available databases such as PubMed and Google scholar were searched for keywords such as probiotics and prebiotics related to human milk, microbiome and milk oligosaccharides. This was further manually curated for inclusion and exclusion criteria relevant to human milk and clinical efficacy. The literature was classified into subgroups and then discussed in detail to facilitate understanding. Although milk research is still in infancy, it is clear that human milk has many functions including protection of infants by passive immunization through secreted antibodies, and transfer of immune regulators, cytokines and bioactive peptides. Unbiased estimates show that the human milk carries a complex community of microbiota which serves as the initial inoculum for establishment of infant gut. Our search effectively screened for evidence that shows that milk also harbours many types of prebiotics such as human milk oligosaccharides which encourage growth of beneficial probiotics. The milk also trains the naive immune system of the infant by supplying immune cells and stimulatory factors, thereby strengthening mucosal and systemic immune system. Our systematic review would improve understanding of human milk and the inherent complexity and diversity of human milk. The interrelated functional role of human milk components especially the oligosaccharides and microbiome has been discussed which plays important role in human health. |
| تدمد: | 1365-2672 1364-5072 |
| DOI: | 10.1111/jam.15078 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f46aca9ef4d4c447fa7d03c18786d6 https://doi.org/10.1111/jam.15078 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....99f46aca9ef4d4c447fa7d03c18786d6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652672 13645072 |
|---|---|
| DOI: | 10.1111/jam.15078 |