Bronchial thermoplasty reduces airway resistance
| العنوان: | Bronchial thermoplasty reduces airway resistance |
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| المؤلفون: | Virginia Plummer, David Langton, Kim Bennetts, Peter B. Noble, Francis Thien |
| المصدر: | Respiratory Research Respiratory Research, Vol 21, Iss 1, Pp 1-8 (2020) |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Spirometry, medicine.medical_specialty, Imaging, 03 medical and health sciences, 0302 clinical medicine, Airway resistance, Internal medicine, medicine, Humans, Plethysmograph, 030212 general & internal medicine, Specific Airway Resistance, Aged, Asthma, lcsh:RC705-779, Bronchial Thermoplasty, Lung, Bronchial thermoplasty, medicine.diagnostic_test, business.industry, Airway Resistance, Research, lcsh:Diseases of the respiratory system, Middle Aged, respiratory system, medicine.disease, Respiratory Function Tests, respiratory tract diseases, Plethysmography, medicine.anatomical_structure, 030228 respiratory system, Cardiology, Female, business, Airway |
| الوصف: | Background The mechanism for symptomatic improvement after bronchial thermoplasty (BT) is unclear, since spirometry reveals little or no change. In this study, the effects of BT on airway resistance were examined using two independent techniques. Methods Eighteen consecutive patients, with severe asthma (57.6 ± 14.2 years) were evaluated by spirometry and plethysmography at three time points: (i) baseline, (ii) left lung treated but right lung untreated and (iii) 6 weeks after both lungs were treated with BT. At each assessment, total and specific airway resistance (Raw, sRaw) were measured. High resolution CT scans were undertaken at the first two assessments, and measurements of lobar volume, airway volume and airway resistance were made. The Asthma Control Questionnaire (ACQ) was administered at each assessment. Results The baseline ACQ score was 3.5 ± 0.9, and improved progressively to 1.8 ± 1.2 (p r = 0.56, p CT scans demonstrated reduced airway volume at baseline, which correlated with the increased Raw determined by plethysmography (p = − 0.536, p = Conclusion Symptomatic improvement after BT is mediated by increased airway volume and reduced airway resistance. |
| تدمد: | 1465-993X |
| DOI: | 10.1186/s12931-020-1330-5 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e01ef49a134174d67ffacfe3a9d6c3 https://doi.org/10.1186/s12931-020-1330-5 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....99e01ef49a134174d67ffacfe3a9d6c3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1465993X |
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| DOI: | 10.1186/s12931-020-1330-5 |