Epidemiological characteristics of nasopharyngeal Streptococcus pneumoniae strains among children with pneumonia in Chongqing, China
| العنوان: | Epidemiological characteristics of nasopharyngeal Streptococcus pneumoniae strains among children with pneumonia in Chongqing, China |
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| المؤلفون: | Yu Gao, Xiaohong Xie, Zhengxiu Luo, Enmei Liu, Yi-Yi Yu, Jian Luo, Yu Deng, Yao Zhang, Luo Ren, Hui Li |
| المصدر: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) |
| بيانات النشر: | Nature Publishing Group UK, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Serotype, Male, China, Microbiological culture, medicine.drug_class, Antibiotics, lcsh:Medicine, Microbial Sensitivity Tests, medicine.disease_cause, Pneumococcal conjugate vaccine, Article, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Lower respiratory tract infection, Nasopharynx, Streptococcus pneumoniae, medicine, Humans, lcsh:Science, Multidisciplinary, business.industry, lcsh:R, Infant, Newborn, Infant, Pneumonia, Pneumococcal, medicine.disease, Penicillin, Pneumonia, 030104 developmental biology, Child, Preschool, lcsh:Q, Female, business, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Streptococcus pneumoniae (pneumococcus) is the most common respiratory pathogen worldwide. Nasopharyngeal carriage with S. pneumoniae is the major source of lower respiratory tract infection and horizontal spread among children. Investigating nasopharyngeal S. pneumoniae is crucial for clinicians to control pneumococcus disease. Here, we retrospectively analyzed clinical information of 5,960 hospitalized children, focusing on pneumonia children less than five years with positive nasopharyngeal pneumococcal cultures. Nasopharyngeal aspirates (NPAs) were collected between June 2009 and December 2016, which were outside the pneumococcal conjugate vaccine(PCV) period. NPAs were subjected to common bacterial culture and antibiotic susceptibility tests, and serotypes were identified by both multiplex PCR and DNA sequencing. Results clearly revealed that clinical manifestations of the children whose NPAs were S. pneumoniae culture positive were serious, especially in those less than twelve months old. Fifteen different serotypes of nasopharyngeal S. pneumoniae were detected, the most common ones being 19F (35.2%), 6A/B (23.8%), 19A (11.4%), 15B/C (9.3%) and 23F (7.8%). Eight serotypes, accounting for 85.5% of the isolates, corresponded to the PCV13 serotypes. Approximately one-third of all S. pneumoniae strains were susceptible to penicillin. Overall, we consider nasopharyngeal S. pneumoniae culture is beneficial in assessing the situations of pneumonia children. Moreover, PCV13 could be useful in preventing pneumococcal disease in Chongqing, China. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99302a56a5a090bd9bee2ed2e6b37cbb http://europepmc.org/articles/PMC6397308 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....99302a56a5a090bd9bee2ed2e6b37cbb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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