التفاصيل البيبلوغرافية
| العنوان: |
Individual variability in behavior and functional networks predicts vulnerability using a predator scent model of PTSD |
| المؤلفون: |
Gregory J. Quirk, Hector Bravo-Rivera, Nanyin Zhang, Yuncong Ma, Alexander Verbitsky, Pablo D. Perez, David Dopfel |
| بيانات النشر: |
Cold Spring Harbor Laboratory, 2018. |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
0303 health sciences, Vulnerability, Functional networks, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Response strategy, chemistry, Corticosterone, Biological neural network, medicine, Anxiety, medicine.symptom, Set (psychology), Psychology, Predator, Neuroscience, 030217 neurology & neurosurgery, 030304 developmental biology |
| الوصف: |
Only a minority of individuals who experience traumatic event(s) subsequently develop post-traumatic stress disorder (PTSD). However, whether differences in vulnerability to PTSD result from predisposition or a consequence of trauma exposure remains unclear. A major challenge in differentiating these possibilities is that clinical studies focus on individuals already exposed to traumatic experiences, and do not take into account pre-trauma conditions. Here using the predator scent model of PTSD in rats and a longitudinal design, we measured pre-trauma brain-wide neural circuit functional connectivity (FC), behavioral and corticosterone responses to trauma exposure, and post-trauma anxiety. Individual differences in freezing responses to predator scent exposure correlated with differences in pre-trauma FC in a set of neural circuits, especially in olfactory and stress-related systems, indicating that pre-existing function in these circuits could predispose animals to differential fearful responses to threats. Counterintuitively, rats with the lowest freezing showed more avoidance of the predator scent, a prolonged corticosterone response, and higher anxiety long after exposure. This study provides a comprehensive framework of pre-existing circuit function that determines threat response strategy, which might be directly related to the development of PTSD-like behaviors. |
| اللغة: |
English |
| DOI: |
10.1101/438952 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b055788488e443be17db192a19dc18 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....98b055788488e443be17db192a19dc18 |
| قاعدة البيانات: |
OpenAIRE |