Cell Entry of Animal Coronaviruses
| العنوان: | Cell Entry of Animal Coronaviruses |
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| المؤلفون: | Xinglin Li, Yang-Ran Cheng, Hanxin Lin, Xuesen Zhao |
| المصدر: | Viruses, Vol 13, Iss 1977, p 1977 (2021) Viruses |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Livestock, Swine, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), viruses, receptor, membrane fusion, proteolytic cleavage, Virus Attachment, Review, Biology, virus entry, medicine.disease_cause, spike protein, Microbiology, Virus, Dogs, Viral entry, attachment factor, Virology, medicine, Animals, cell binding, Coronavirus, Cell entry, RNA, Lipid bilayer fusion, virus diseases, Virus Internalization, QR1-502, respiratory tract diseases, Viral Tropism, Infectious Diseases, animal coronaviruses, Spike Glycoprotein, Coronavirus, Cats, Tissue tropism, host restriction factor, Receptors, Virus, Cattle, Coronavirus Infections, Chickens |
| الوصف: | Coronaviruses (CoVs) are a group of enveloped positive-sense RNA viruses and can cause deadly diseases in animals and humans. Cell entry is the first and essential step of successful virus infection and can be divided into two ongoing steps: cell binding and membrane fusion. Over the past two decades, stimulated by the global outbreak of SARS-CoV and pandemic of SARS-CoV-2, numerous efforts have been made in the CoV research. As a result, significant progress has been achieved in our understanding of the cell entry process. Here, we review the current knowledge of this essential process, including the viral and host components involved in cell binding and membrane fusion, molecular mechanisms of their interactions, and the sites of virus entry. We highlight the recent findings of host restriction factors that inhibit CoVs entry. This knowledge not only enhances our understanding of the cell entry process, pathogenesis, tissue tropism, host range, and interspecies-transmission of CoVs but also provides a theoretical basis to design effective preventive and therapeutic strategies to control CoVs infection. |
| اللغة: | English |
| تدمد: | 1999-4915 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d32ae8748633d02a4d92214d8e187d https://www.mdpi.com/1999-4915/13/10/1977 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....97d32ae8748633d02a4d92214d8e187d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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