Forward and reverse translational approaches to predict efficacy of neutralizing respiratory syncytial virus (RSV) antibody prophylaxis
| العنوان: | Forward and reverse translational approaches to predict efficacy of neutralizing respiratory syncytial virus (RSV) antibody prophylaxis |
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| المؤلفون: | Francesco Bellanti, Antonios O. Aliprantis, Juin Fok-Seang, Wen Liu, Jeffrey R. Sachs, Radha Railkar, Brad Roadcap, Kalpit A. Vora, Qinlei Huang, Li Qin, Nele Plock, W. Gao, Eseng Lai, Daniel S. Spellman, Jingxian Chen, Andrew P. Catchpole, Emilie Schindler, Mariya Kalinova, Amy S. Espeseth, Jie Meng, S. Y. Amy Cheung, Luzelena Caro, S. Aubrey Stoch, Benjamin Guiastrennec, Jos Lommerse, Brian M. Maas, Ying Zhang, Han Witjes |
| المصدر: | EBioMedicine, Vol 73, Iss, Pp 103651-(2021) EBioMedicine |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Medicine (General), Research paper, Adolescent, medicine.drug_class, Premedication, Monoclonal Antibody, Force of infection, Respiratory Syncytial Virus Infections, Antibodies, Viral, Monoclonal antibody, medicine.disease_cause, Placebo, General Biochemistry, Genetics and Molecular Biology, Virus, Translational Research, Biomedical, Young Adult, R5-920, Modelling and Simulation, Clinical endpoint, Humans, Medicine, Aged, RSV, Meta-analysis, Clinical Trials as Topic, biology, business.industry, Incidence, Antibodies, Monoclonal, Human Challenge Study, General Medicine, Middle Aged, Models, Theoretical, Antibodies, Neutralizing, Clinical trial, Respiratory syncytial virus (RSV), Respiratory Syncytial Virus, Human, Immunology, biology.protein, Female, Seasons, Respiratory Syncytial Virus, Antibody, business, Algorithms |
| الوصف: | Background Neutralizing mAbs can prevent communicable viral diseases. MK-1654 is a respiratory syncytial virus (RSV) F glycoprotein neutralizing monoclonal antibody (mAb) under development to prevent RSV infection in infants. Development and validation of methods to predict efficacious doses of neutralizing antibodies across patient populations exposed to a time-varying force of infection (i.e., seasonal variation) are necessary. Methods Five decades of clinical trial literature were leveraged to build a model-based meta-analysis (MBMA) describing the relationship between RSV serum neutralizing activity (SNA) and clinical endpoints. The MBMA was validated by backward translation to animal challenge experiments and forward translation to predict results of a recent RSV mAb trial. MBMA predictions were evaluated against a human trial of 70 participants who received either placebo or one of four dose-levels of MK-1654 and were challenged with RSV [NCT04086472]. The MBMA was used to perform clinical trial simulations and predict efficacy of MK-1654 in the infant target population. Findings The MBMA established a quantitative relationship between RSV SNA and clinical endpoints. This relationship was quantitatively consistent with animal model challenge experiments and results of a recently published clinical trial. Additionally, SNA elicited by increasing doses of MK-1654 in humans reduced RSV symptomatic infection rates with a quantitative relationship that approximated the MBMA. The MBMA indicated a high probability that a single dose of ≥ 75 mg of MK-1654 will result in prophylactic efficacy (> 75% for 5 months) in infants. Interpretation An MBMA approach can predict efficacy of neutralizing antibodies against RSV and potentially other respiratory pathogens. |
| تدمد: | 2352-3964 |
| DOI: | 10.1016/j.ebiom.2021.103651 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979efaad60d5195380f7df59609ee178 https://doi.org/10.1016/j.ebiom.2021.103651 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....979efaad60d5195380f7df59609ee178 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2021.103651 |