Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments
| العنوان: | Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments |
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| المؤلفون: | Niklas Wilming, Genis Prat Ortega, Peter R. Murphy, Tobias H. Donner, Diana C. Hernandez-Bocanegra |
| المصدر: | Nature Neuroscience. 24:987-997 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Computer science, Decision Making, Models, Neurological, Population, Sensory system, Arousal, 03 medical and health sciences, 0302 clinical medicine, Cortex (anatomy), medicine, Humans, Sensory cortex, education, Associative property, Cerebral Cortex, education.field_of_study, medicine.diagnostic_test, General Neuroscience, Magnetoencephalography, Angewandte Kognitionswissenschaft, Visual evidence, 030104 developmental biology, medicine.anatomical_structure, Visual cortex, Cerebral cortex, Dynamics (music), Normative, Female, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Many decisions under uncertainty entail the temporal accumulation of evidence that informs about the state of the environment. When environments are subject to hidden changes in their state, maximizing accuracy and reward requires non-linear accumulation of the evidence. How this adaptive, non-linear computation is realized in the brain is unknown. We analyzed human behavior and cortical population activity (measured with magnetoencephalography) recorded during visual evidence accumulation in a changing environment. Behavior and decision-related activity in cortical regions involved in action planning exhibited hallmarks of adaptive evidence accumulation, which could also be implemented by a recurrent cortical microcircuit. Decision dynamics in action-encoding parietal and frontal regions were mirrored in a frequency-specific modulation of the state of visual cortex that depended on pupil-linked arousal and the expected probability of change. These findings link normative decision computations to recurrent cortical circuit dynamics and highlight the adaptive nature of decision-related feedback to sensory cortex. |
| تدمد: | 1546-1726 1097-6256 |
| DOI: | 10.1038/s41593-021-00839-z |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9758bdc8af3034ae7022d76ccd5a18ab https://doi.org/10.1038/s41593-021-00839-z |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9758bdc8af3034ae7022d76ccd5a18ab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15461726 10976256 |
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| DOI: | 10.1038/s41593-021-00839-z |