Congenitally determined neurodegeneration 'lurcher' induces morphofunctional changes of thymus
| العنوان: | Congenitally determined neurodegeneration 'lurcher' induces morphofunctional changes of thymus |
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| المؤلفون: | J. Slípka, Mandáková P, Virtová M, Petr Sima, Beranová M |
| المصدر: | Folia Microbiologica. 48:394-398 |
| بيانات النشر: | Springer Science and Business Media LLC, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Lurcher Mice, Lurcher, Apoptosis, Enzyme-Linked Immunosorbent Assay, Thymus Gland, Biology, Microbiology, Flow cytometry, Mice, Mice, Neurologic Mutants, Necrosis, Immune system, medicine, Animals, Medulla, Mice, Inbred C3H, Thymic cortex, medicine.diagnostic_test, Neurodegeneration, General Medicine, Flow Cytometry, medicine.disease, Nerve Degeneration, Immunology, Female |
| الوصف: | A significantly higher frequency of apoptosis was documented by flow cytometry and by ELISA analysis, and significantly higher numbers of necrotic cells were demonstrated by ELISA within the thymus of Lurcher mice in comparison with the control C3H mice. These can be regarded as important markers of degenerative changes in this primary immune organ. This tendency is supported by histological observation of the absence of a clear interface between thymic cortex and medulla and an insignificantly increased number of Hassall's corpuscles resembling an onset of thymic atrophy. |
| تدمد: | 1874-9356 0015-5632 |
| DOI: | 10.1007/bf02931373 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b504f628f8f541573e0fe8ac306b28 https://doi.org/10.1007/bf02931373 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....96b504f628f8f541573e0fe8ac306b28 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18749356 00155632 |
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| DOI: | 10.1007/bf02931373 |