Neurodevelopmental disorders in children exposed in utero to synthetic progestins: analysis from the national cohort of the Hhorages Association*
| العنوان: | Neurodevelopmental disorders in children exposed in utero to synthetic progestins: analysis from the national cohort of the Hhorages Association* |
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| المؤلفون: | Françoise Paris, Philippe Courtet, Marie-Odile Soyer-Gobillard, Mauricette Puillandre, Laura Gaspari, Charles Sultan |
| المساهمون: | Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| المصدر: | Gynecological Endocrinology Gynecological Endocrinology, Taylor & Francis, 2019, 35 (3), pp.247-250. ⟨10.1080/09513590.2018.1512968⟩ |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, adulthood, Adolescent, Endocrinology, Diabetes and Metabolism, Physiology, 030209 endocrinology & metabolism, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, National cohort, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Synthetic Progestins, Pregnancy, Surveys and Questionnaires, Humans, Medicine, Child, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, 030219 obstetrics & reproductive medicine, Progesterone Congeners, business.industry, Obstetrics and Gynecology, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Adolescence, 3. Good health, psychiatric disorders, Neurodevelopmental Disorders, In utero, Prenatal Exposure Delayed Effects, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, prenatal progestin exposure, Hormone |
| الوصف: | International audience; The medical and scientific communities have not yet fully acknowledged the undesirable effects of the synthetic hormones that have been administered to pregnant women for decades. The somatic effects of in utero exposure to diethylstilbestrol (DES), such as genital malformations, infertility, and cancer, have long been recognized but this has not been the case concerning psychiatric disorders. The progestins used in contraception and hormone replacement therapy are known to affect the adult brain, but no data exist on their effects due to in utero exposure of children. The Hhorages Association, a national patient support group, has assembled a cohort of 1200 women who took synthetic hormones during pregnancy. These women had a combined 1934 children. We obtained full questionnaire responses from 46 women treated with progestins only – and not an estrogenic cocktail – who gave birth to 115 children. Three groups were observed: Group 1 (n = 18): firstborn unexposed children, Group 2 (n = 62): children exposed in utero to synthetic progestins, and Group 3 (n = 35): children born after a previous pregnancy treated with progestins. No psychiatric disorders were reported in Group 1 and the incidence of psychiatric disorders was drastically elevated in Group 2. Our work shows a striking increase in psychiatric disorders among children exposed in utero to progestins and strongly suggests that prenatal exposure is associated with a high risk of psychiatric disorders in adolescence and adulthood, whether accompanied or not by disorders of sex development.; 医学界和科学界尚未充分认识到几十年来孕妇用合成激素的不良影响。宫内暴露于己烯雌酚（DES）对躯体的影响, 例如生殖器畸形, 不孕和癌症, 早已被人们认识到, 但对于精神疾病的影响却没有被认识到。众所周知, 用于避孕和激素替代治疗的孕激素会影响成年人的大脑, 但没有关于儿童在宫内时的暴露对其影响的数据。Hhorages 学会, 全国患者支持小组, 汇集了1200名在怀孕期间服用过合成激素的女性。这些女性共有1934名儿童。我们获得了仅接受孕激素治疗的46名女性完整调查问卷, 而不是雌激素鸡尾酒, 她们生下了115名孩子。观察3组：组1（n=18）：第一胎未暴露儿童, 组2（n=62）：宫内暴露于合成孕激素, 组3（n=35）：前一次怀孕用孕激素治疗, 之后出生的孩子。第1组未报告精神疾病, 第2组精神疾病发病率急剧上升。我们的研究表明, 宫内暴露于孕激素的儿童精神疾病发生率显著增加, 并强烈表明产前暴露与青春期和成年期精神疾病的高风险相关, 无论是否伴有性发育障碍。 |
| تدمد: | 1473-0766 0951-3590 |
| DOI: | 10.1080/09513590.2018.1512968 |
| DOI: | 10.1080/09513590.2018.1512968⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964e328880cf0c6d61ac3f3f9c260c6e https://doi.org/10.1080/09513590.2018.1512968 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....964e328880cf0c6d61ac3f3f9c260c6e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14730766 09513590 |
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| DOI: | 10.1080/09513590.2018.1512968 |