Influenza Vaccination for Immunocompromised Patients: Systematic Review and Meta-Analysis from a Public Health Policy Perspective
| العنوان: | Influenza Vaccination for Immunocompromised Patients: Systematic Review and Meta-Analysis from a Public Health Policy Perspective |
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| المؤلفون: | Julia Rosser, Rebecca Harris, Javier Peñalver, Dean Wallace, Lauren Ahyow, Arina Zanuzdana, Richard Puleston, Felix Greaves, Jonathan S. Nguyen-Van-Tam, David A. Ishola, Bruce C. McKenzie, Caroline Hird, Helene Denness, Jose Figureroa, Ahmed Hashim, Neil Wigglesworth, Mitsuru Mukaigawara, Rachel Weston, Sarah Theaker, Marko Kerac, Mobasher Butt, Elizabeth Orton, Liz Lingard, Charles R. Beck, Gemma S Morgan, Munib Haroon, Julie O'Boyle, Girija Dabke, Sophie Haroon, Gabriel Agboado, Joanne E. Enstone, Charlotte Stevenson, Hiroshi Horiuchi, Vivienne Parish, Jonathan Roberts, Mary O'Brien, Robert Howard, Rachel Isba, Laura Béchard-Evans, Glenda Augustine, Sophie Kim, Yana Vinogradova, Siobhan Farmer, Paul Fisher |
| المصدر: | PLoS ONE, Vol 6, Iss 12, p e29249 (2011) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Viral Diseases, Placebo-controlled study, PLACEBO-CONTROLLED TRIAL, Placebos, Medicine, Infection control, Immune Response, Vaccines, ACTIVE ANTIRETROVIRAL THERAPY, Multidisciplinary, Health Policy, Vaccination, Infectious Diseases, Influenza Vaccines, Meta-analysis, HUMAN-IMMUNODEFICIENCY-VIRUS, Science & Technology - Other Topics, Public Health, Research Article, Funnel plot, medicine.medical_specialty, Systematic Reviews, General Science & Technology, Clinical Research Design, Science, Immunology, HEART-TRANSPLANT RECIPIENTS, Immunocompromised Host, Internal medicine, MD Multidisciplinary, Humans, Seroconversion, Biology, ACUTE LYMPHOBLASTIC-LEUKEMIA, Science & Technology, MULTIDISCIPLINARY SCIENCES, business.industry, Immunity, STEM-CELL TRANSPLANTATION, HIV-INFECTED INDIVIDUALS, Publication bias, Odds ratio, SERUM ANTIBODY-RESPONSE, Influenza, HUMORAL IMMUNE-RESPONSE, Immune System, Clinical Immunology, Meta-Analyses, business, INFLAMMATORY-BOWEL-DISEASE |
| الوصف: | BackgroundImmunocompromised patients are vulnerable to severe or complicated influenza infection. Vaccination is widely recommended for this group. This systematic review and meta-analysis assesses influenza vaccination for immunocompromised patients in terms of preventing influenza-like illness and laboratory confirmed influenza, serological response and adverse events.Methodology/principal findingsElectronic databases and grey literature were searched and records were screened against eligibility criteria. Data extraction and risk of bias assessments were performed in duplicate. Results were synthesised narratively and meta-analyses were conducted where feasible. Heterogeneity was assessed using I(2) and publication bias was assessed using Begg's funnel plot and Egger's regression test. Many of the 209 eligible studies included an unclear or high risk of bias. Meta-analyses showed a significant effect of preventing influenza-like illness (odds ratio [OR]=0.23; 95% confidence interval [CI]=0.16-0.34; pConclusions/significanceInfection prevention and control strategies should recommend vaccinating immunocompromised patients. Potential for bias and confounding and the presence of heterogeneity mean the evidence reviewed is generally weak, although the directions of effects are consistent. Areas for further research are identified. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fda53fdf2f32203364919d9c05a05e https://pub.uni-bielefeld.de/record/2476447 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....95fda53fdf2f32203364919d9c05a05e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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