Endocrinology and the brain: corticotropin-releasing hormone signaling
| العنوان: | Endocrinology and the brain: corticotropin-releasing hormone signaling |
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| المؤلفون: | Paula A dos Santos Claro, Natalia G Armando, Susana Silberstein, Carolina Inda |
| المصدر: | Endocrine Connections Endocrine Connections, Vol 6, Iss 6, Pp R99-R120 (2017) CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| بيانات النشر: | Bioscientifica, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, endocrine system, medicine.medical_specialty, GPCR endocytosis and signaling, Otras Ciencias Biológicas, Endocrinology, Diabetes and Metabolism, Review, lcsh:Diseases of the endocrine glands. Clinical endocrinology, GPCR Signaling, purl.org/becyt/ford/1 [https], Ciencias Biológicas, 03 medical and health sciences, Corticotropin-releasing hormone, CRH system pathophysiology, Endocrinology, Molecular level, cAMP, Internal medicine, Internal Medicine, medicine, purl.org/becyt/ford/1.6 [https], Receptor, CYCLIC AMP, CRH RECEPTOR SIGNALING, G protein-coupled receptor, lcsh:RC648-665, ERK1/2, business.industry, CRH receptors signaling, CRH SYSTEM PATHOPHYSIOLOGY, Editor's Choice, 030104 developmental biology, business, CIENCIAS NATURALES Y EXACTAS, hormones, hormone substitutes, and hormone antagonists, Function (biology), Hormone |
| الوصف: | Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral adaptive responses to stress. This review describes molecular components and cellular mechanisms involved in CRH signaling downstream of its G protein-coupled receptors (GPCRs) CRHR1 and CRHR2, and summarizes recent findings that challenge the classical view of GPCR signaling, and impact on our understanding of CRHRs function. Special emphasis is placed on recent studies of CRH signaling that revealed new mechanistic aspects of cAMP generation and ERK1/2 activation in physiologically relevant contexts of the neurohormone action. In addition, we present an overview of the pathophysiological role of the CRH system, which highlights the need for a precise definition of CRHRs signaling at molecular level to identify novel targets for pharmacological intervention in neuroendocrine tissues and specific brain areas involved in CRH-related disorders. Fil: Inda, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina Fil: Armando, Natalia Giannina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina Fil: Dos Santos Claro, Paula Ayelen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina Fil: Silberstein Cuña, Susana Iris. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina |
| وصف الملف: | application/pdf |
| تدمد: | 2049-3614 |
| DOI: | 10.1530/ec-17-0111 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d1b74e3969044c1649e3dbbec23505 https://doi.org/10.1530/ec-17-0111 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....95d1b74e3969044c1649e3dbbec23505 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20493614 |
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| DOI: | 10.1530/ec-17-0111 |