SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation
| العنوان: | SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation |
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| المؤلفون: | Xiao-Xiao Guo, Ayanlaja Abiola Abdulrahman, Kouminin Kanwore, Iqra Nadeem, Dianshuai Gao, Piniel Alphayo Kambey |
| المصدر: | Molecular Neurobiology. 58:2634-2642 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male sex determination, Cell, Neuroscience (miscellaneous), Biology, medicine.disease_cause, Neuroprotection, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, SOX1, Glioma, medicine, Animals, Humans, Cell Proliferation, Neurons, Cell growth, SOXB1 Transcription Factors, Brain, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Neurology, Neoplastic Stem Cells, Stem cell, Carcinogenesis, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Failed neuroprotection leads to the initiation of several diseases. SOX1 plays many roles in embryogenesis, oncogenesis, and male sex determination, and can promote glioma stem cell proliferation, invasion, and migration due to its high expression in glioblastoma cells. The functional versatility of the SOX1 gene in malignancy, epilepsy, and Parkinson's disease, as well as its adverse effects on dopaminergic neurons, makes it an interesting research focus. Hence, we collate the most important discoveries relating to the neuroprotective effects of SOX1 in brain cancer and propose hypothesis worthy of SOX1's role in the survival of senescent neuronal cells, its roles in fibroblast cell proliferation, and cell fat for neuroprotection, and the discharge of electrical impulses for homeostasis. Increase in electrical impulses transmitted by senescent cells affects the synthesis of neurotransmitters, which will modify the brain cell metabolism and microenvironment. |
| تدمد: | 1559-1182 0893-7648 |
| DOI: | 10.1007/s12035-020-02240-6 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b991e65d84105bbb0f7ced9b1386b0 https://doi.org/10.1007/s12035-020-02240-6 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....95b991e65d84105bbb0f7ced9b1386b0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15591182 08937648 |
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| DOI: | 10.1007/s12035-020-02240-6 |