New Antimony(III) Bromide Complexes with Thioamides: Synthesis, Characterization, and Cytostatic Properties
| العنوان: | New Antimony(III) Bromide Complexes with Thioamides: Synthesis, Characterization, and Cytostatic Properties |
|---|---|
| المؤلفون: | Ozturk, I. I., Hadjikakou, Sotiris K., Hadjiliadis, Nick, Kourkoumelis, Nikolaos, Kubicki, Maciej, Tasiopoulos, Anastasios J., Scleiman, H., Barsan, M. M., Butler, I. S., Balzarini, J. |
| المساهمون: | Tasiopoulos, Anastasios J. [0000-0002-4804-3822], Hadjikakou, Sotiris K. [0000-0001-9556-6266] |
| المصدر: | Inorganic chemistry Inorg.Chem. |
| بيانات النشر: | American Chemical Society (ACS), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Antimony, Models, Molecular, synthesis, Ionic bonding, Crystal structure, Crystallography, X-Ray, Cell Proliferation/drug effects, chemistry.chemical_compound, Bromide, molecular-orbital methods, animal, Thioamide, chemistry.chemical_classification, density, drug effect, article, Cytostatic Agents/*chemical synthesis/chemistry/*pharmacology, Thiourea, Antimony/*chemistry, organometallic compound, crystal-structures, Bromides, cytostatic agent, Stereochemistry, antimony, chemistry.chemical_element, chemistry, Organometallic Compounds/*chemical synthesis/chemistry/*pharmacology, Inorganic Chemistry, Cell Line, Tumor, computer simulation, Organometallic Compounds, Humans, Animals, series, Computer Simulation, human, Physical and Theoretical Chemistry, Cell Proliferation, bromide, ligands, exchange, tumor cell line, thioamide, X ray crystallography, Cytostatic Agents, basis sets, Thioamides/*chemistry, Square pyramidal molecular geometry, Thioamides, Crystallography, cell proliferation, Octahedron, chemical structure, Bromides/*chemistry |
| الوصف: | New antimony(III) bromide complexes with the heterocyclic thioamides, thiourea (TU), 2-mercapto-1-methylimidazole (MMI), 2-mercapto-benzimidazole (MBZIM), 2-mercapto-5-methyl-benzimidazole (MMBZIM), 5-ethoxy-2-mercapto-benzimidazole (EtMBZIM), 2-mercapto-3,4,5,6-tetrahydro-pyrimidine (tHPMT), 2-mercaptopyridine (PYT), 2-mercapto-thiazolidine (MTZD), 3-methyl-2-mercaptobenzothiazole (MMBZT), and 2-mercaptopyrimidine (PMTH) of formulas [SbBr(3)(TU)(2)] (1), [SbBr(3)(MMI)(2)] (2), {[SbBr(2)(MBZIM)(4)](+) [Br](-) H(2)O} (3), {[SbBr(2)(mu(2)-Br)(MMBZIM)(2)](2)} (4), {[SbBr(2)(mu(2)-Br)(EtMBZIM)(2)](2) MeOH} (5), {[SbBr(3)(mu(2)- S-tHPMT)(tHPMT)](n)} (6), ([SbBr(2)(mu(2)-Br)(PYT)(2))(n)} (7), {[SbBr(2)(mu(2)-Br)(MTZD)(2)](n)} (8), [SbBr(3)(MMBZT)(2)] (9), and {[SbBr(5)](2-) [(PMTH(2)(+))(2)]} (10) have been synthesized and characterized by elemental analysis, conductivity measurements, FTIR spectroscopy, FT-Raman spectroscopy, TG-DTA analysis, and X-ray powder diffraction. The crystal structures of 3, 4, 5, 6, 7, 8, and 10 were also determined by X-ray diffraction. In 3, four sulfur atoms from thione ligands and two bromide ions form an octahedral (O(h)) cationic [SbS(4)Br(2)](+) species in which the two bromide anions lie at axial positions. A third bromide counteranion neutralizes the whole complex. 4 and 5 are dimers, whereas 6, 7 and 8 are polymers, built up by monomeric units of square pyramidal (SP) geometry around the metal center, which were formed by two sulfur atoms of thioamide ligands and three bromide ions. Finally, 10 is ionic salt containing 1D polymeric network of {[SbBr(5)](2-)}(n) anions and -[(PMTH(2)(+))(2)] counter cations. in the lattice. The complexes showed mostly a moderate cytostatic activity against a variety of tumor cell lines. Inorg Chem |
| تدمد: | 1520-510X 0020-1669 |
| DOI: | 10.1021/ic8019205 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9508b919f93c1383188b1f7c963faea7 https://doi.org/10.1021/ic8019205 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9508b919f93c1383188b1f7c963faea7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1520510X 00201669 |
|---|---|
| DOI: | 10.1021/ic8019205 |