Prognostic factors in the intellectual development at 7 years of age in children with congenital hypothyroidism
| العنوان: | Prognostic factors in the intellectual development at 7 years of age in children with congenital hypothyroidism |
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| المؤلفون: | A. Tenore, S. Di Maio, M. Salerno, Roberto Militerni, Giuliana Valerio, A. Argenziano |
| المساهمون: | Salerno, Mariacarolina, S., Di Maio, R., Militerni, A., Argenziano, G., Valerio, A. T. e. n. o. r., E. |
| المصدر: | Scopus-Elsevier |
| بيانات النشر: | Springer Science and Business Media LLC, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Pediatrics, Intellectual development, Endocrinology, Diabetes and Metabolism, Initial dose, Intelligence, intellectual development, Child Development, Endocrinology, Hypothyroidism, Internal medicine, Congenital Hypothyroidism, medicine, neonatal screening, Humans, Child, Normal range, thyroid hormones, Intelligence Tests, Psychomotor learning, business.industry, Bone age, Prognosis, medicine.disease, Congenital hypothyroidism, Thyroxine, El Niño, Thyroid hormones, Female, business |
| الوصف: | The influence of the initial L-T4 dose and some other factors on the intellectual development was evaluated at 7 years of age in 47 congenitally hypothyroid children detected by the regional screening program. All patients were initially treated with 25 micrograms LT4/kg/day that represented a mean replacement dose of 6.8 +/- 1.3 micrograms/kg. Despite the "low" initial dose mean IQ at 7 years resulted within normal range (96 +/- 9). Twenty-eight patients initially treated with 6.0 +/- 0.6 micrograms L-T4/kg/day had a mean IQ (96 +/- 9) which was not different with respect to 19 patients (IQ 94 +/- 7) treated with a significantly higher L-T4 dose (8.1 +/- 0.9 micrograms/kg/day; p0.0001). The initial L-T4, dose did not correlate with IQ at 7 years whereas a significant correlation was found between IQ and serum T4 concentration at diagnosis (r = 0.35; p0.01) regardless of the fact that serum T4 concentration normalized after the first 2 months of therapy in both groups. Twenty-three patients whose serum T4 at diagnosis was2 micrograms/dl (1.0 +/- 0.5) had a mean IQ at 7 years (92 +/- 9) which was significantly lower than the 24 patients (IQ 98 +/- 7; p0.02) whose serum T4 was2 micrograms/dl (5.7 +/- 2.4; p0.001). The present findings suggest that the severity of neonatal hypothyroidism is an important factor in determining subsequent intellectual development of congenitally hypothyroid children. |
| وصف الملف: | STAMPA |
| تدمد: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03349810 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9451814b8c053c9072cb16b823a0c36e https://doi.org/10.1007/bf03349810 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9451814b8c053c9072cb16b823a0c36e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17208386 03914097 |
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| DOI: | 10.1007/bf03349810 |