Limited value of 18F-FDG PET/CT and S-100B tumour marker in the detection of liver metastases from uveal melanoma compared to liver metastases from cutaneous melanoma
| العنوان: | Limited value of 18F-FDG PET/CT and S-100B tumour marker in the detection of liver metastases from uveal melanoma compared to liver metastases from cutaneous melanoma |
|---|---|
| المؤلفون: | Dorothee R. Fischer, Patrick Veit-Haibach, Laurence Imhof, Simone M. Goldinger, Klaus Strobel, Reinhard Dummer, G. K. von Schulthess, Hans C. Steinert, Beata Bode |
| المساهمون: | University of Zurich, Strobel, K |
| المصدر: | European Journal of Nuclear Medicine and Molecular Imaging. 36:1774-1782 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, Uveal Neoplasms, Oncology, medicine.medical_specialty, Skin Neoplasms, Receptor expression, 610 Medicine & health, Standardized uptake value, S100 Calcium Binding Protein beta Subunit, Fluorodeoxyglucose F18, 10049 Institute of Pathology and Molecular Pathology, Cytology, Internal medicine, Biomarkers, Tumor, Humans, 2741 Radiology, Nuclear Medicine and Imaging, Medicine, Radiology, Nuclear Medicine and imaging, Nerve Growth Factors, Patient group, Melanoma, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Liver Neoplasms, S100 Proteins, 10177 Dermatology Clinic, Histology, 10181 Clinic for Nuclear Medicine, General Medicine, Middle Aged, Prognosis, medicine.disease, Positron-Emission Tomography, Cutaneous melanoma, Female, Fdg pet ct, Tomography, X-Ray Computed, Nuclear medicine, business |
| الوصف: | Purpose: The objective of this study was to evaluate the value of 18F-FDG PET/CT and S-100B tumour marker for the detection of liver metastases from uveal melanoma in comparison to liver metastases from cutaneous melanoma. Methods: A retrospective evaluation was conducted of 27 liver metastases in 13 patients with uveal melanoma (UM) (mean age: 56.8, range: 30-77) and 43 liver metastases in 14 patients (mean age: 57.9, range: 40-82) with cutaneous melanoma (CM) regarding size and FDG uptake by measuring the maximum standardized uptake value (SUVmax). S-100B serum tumour markers were available in 20 patients. Cytology, histology, additional morphological imaging and follow-up served as reference standard. In nine patients liver metastases were further evaluated histologically regarding GLUT-1 and S-100 receptor expression and regarding epithelial or spindle cell growth pattern. Results: Of 27 liver metastases in 6 of 13 patients (46%) with UM, 16 (59%) were FDG negative, whereas all liver metastases from CM were positive. Liver metastases from UM showed significantly (p |
| وصف الملف: | Strobel_EurJNucMedMolImag_2009-V.pdf - application/pdf; ZORA_NL_27891.pdf - application/pdf |
| تدمد: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s00259-009-1175-0 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cd1bb186b78a68284bed9095bfe3d5 https://doi.org/10.1007/s00259-009-1175-0 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....93cd1bb186b78a68284bed9095bfe3d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16197089 16197070 |
|---|---|
| DOI: | 10.1007/s00259-009-1175-0 |