Precursor fractions of neurotensin and enkephalin might point to molecular mechanisms of cancer risk modulation during a lifestyle-intervention in germline BRCA1/2 gene mutation carriers
| العنوان: | Precursor fractions of neurotensin and enkephalin might point to molecular mechanisms of cancer risk modulation during a lifestyle-intervention in germline BRCA1/2 gene mutation carriers |
|---|---|
| المؤلفون: | Anika Berling-Ernst, Sabine Grill, Maryam Yahiaoui-Doktor, Kerstin Rhiem, Jacqueline Lammert, Janin Schulte, Mirjam Ullrich, Thorsten Schmidt, Christoph Engel, Dimitrios Chronas, Uwe Niederberger, Marion Kiechle, M Basrai, Stephan C. Bischoff, Joachim Struck, Rita K. Schmutzler, Martin Halle |
| المصدر: | Breast Cancer Research and Treatment |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Lifestyle intervention, Oncology, Cancer Research, medicine.medical_specialty, BRCA1/2 mutation carriers, Population, Breast Neoplasms, Disease, 030204 cardiovascular system & hematology, Gene mutation, medicine.disease_cause, Cardiopulmonary fitness, 03 medical and health sciences, Breast cancer, 0302 clinical medicine, Internal medicine, medicine, Humans, education, Life Style, Germ-Line Mutation, Neurotensin, Nutrition, education.field_of_study, Physical activity, BRCA1 Protein, business.industry, Cancer, Enkephalins, medicine.disease, Clinical Trial, ddc, Germ Cells, 030220 oncology & carcinogenesis, Mutation, Cohort, Female, business, Ovarian cancer, Carcinogenesis |
| الوصف: | BackgroundGermlineBRCA1/2mutation carriers (gBMC) face increased cancer risks that are modulated via non-genetic lifestyle factors whose underlying molecular mechanisms are unknown. The peptides Neurotensin (NT) and Enkephalin (ENK)—involved in tumorigenesis and obesity-related diseases—are of interest. We wanted to know whether these biomarkers differ between gBMC and women from the general population and what effect a 1-year lifestyle-intervention has in gBMC.MethodsThe stable precursor fragments pro-NT and pro-ENK were measured at study entry (SE), after 3 and 12 months for 68 women from LIBRE-1 (a controlled lifestyle-intervention feasibility trial for gBMC involving structured endurance training and the Mediterranean Diet). The SE values were compared with a cohort of the general population including female subjects with and without previous cancer disease, non-suggestive for hereditary breast and ovarian cancer (OMA-reference). For LIBRE-1, we analysed the association between the intervention-related change in the two biomarkers and certain lifestyle factors.ResultsAt SE, gBMC had a higher median pro-NT than OMA-reference (in the subgroups with previous cancer 117 vs. 91 pmol/L,p = 0.002). Non-diseased gBMC had lower median pro-ENK levels when compared to the non-diseased reference group. VO2peak and pro-NT 1-year change in LIBRE-1 were inversely correlated (r = − 0.435; CI − 0.653 to − 0.151;p = 0.004). Pro-ENK correlated positively with VO2peak at SE (r = 0.323; CI 0.061–0.544;p = 0.017). Regression analyses showed an inverse association of 1-year changes for pro-NT and Omega-6/Omega-3 (Estimate: − 37.9,p = 0.097/0.080) in multivariate analysis.ConclusionOur results give first indications for lifestyle-related modification particularly of pro-NT in gBMC. |
| وصف الملف: | application/pdf |
| تدمد: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-020-06070-x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c7e4d933be69fc028a3408ea0f62d7 https://doi.org/10.1007/s10549-020-06070-x |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....93c7e4d933be69fc028a3408ea0f62d7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737217 01676806 |
|---|---|
| DOI: | 10.1007/s10549-020-06070-x |