Purpose To report a case of Staphylococcus hominis endophthalmitis associated with a capsular hypopyon. Design Interventional case report. Methods A 51-year-old man presented with chronic postcataract extraction inflammation and underwent vitrectomy, partial capsulectomy, and intravitreal antibiotic injections, followed by explantation of the intraocular lens and capsule. Results A capsular hypopyon in the absence of an anterior chamber hypopyon was noted. Cultures of the vitreous and capsule revealed Staphylococcus hominis , a coagulase-negative gram-positive organism. Conclusions We are unaware of previous reports of endophthalmitis caused by Staphylococcus hominis , and could find none in a computerized search using MEDLINE. This case adds Staphylococcus hominis to the list of causative organisms in chronic endophthalmitis and illustrates the rare finding of a capsular hypopyon.