Ghrelin treatment reverses the reduction in weight gain and body fat in gastrectomised mice
| العنوان: | Ghrelin treatment reverses the reduction in weight gain and body fat in gastrectomised mice |
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| المؤلفون: | Y C L Tung, Suzanne L. Dickson, Rolf Håkanson, Andreas Lindqvist, C. Dornonville de la Cour, Claes Ohlsson, Charlotte Erlanson-Albertsson, Vikas Surve, Emil Egecioglu, J-O Jansson |
| المصدر: | Gut; 54(7), pp 907-913 (2005) |
| بيانات النشر: | BMJ, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | medicine.medical_specialty, food intake, Peptide Hormones, medicine.medical_treatment, Adipose tissue, Gastroenterology and Hepatology, Peptide hormone, Weight Gain, Eating, Mice, body weight, Bone Density, Gastrectomy, Weight loss, Internal medicine, Animals, Medicine, Femur, Postoperative Period, business.industry, digestive, oral, and skin physiology, Gastric Physiology, Gastroenterology, medicine.disease, Obesity, Ghrelin, gastrectomy, body fat, Endocrinology, Adipose Tissue, ghrelin, Body Composition, Lean body mass, Female, medicine.symptom, business, Weight gain, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | Background and aims: The gastric hormone ghrelin has been reported to stimulate food intake, increase weight gain, and cause obesity but its precise physiological role remains unclear. We investigated the long term effects of gastrectomy evoked ghrelin deficiency and of daily ghrelin injections on daily food intake, body weight, fat mass, lean body mass, and bone mass in mice. Methods: Ghrelin was given by subcutaneous injections (12 nmol/mouse once daily) for eight weeks to young female mice subjected to gastrectomy or sham operation one week previously. Results: Gastrectomy reduced plasma concentrations of total ghrelin (octanoylated and des-octanoylated) and active (octanoylated) ghrelin by ~80%. Immediately after injection of ghrelin, the plasma concentration was supraphysiological and was still elevated 16 hours later. Daily food intake was not affected by either gastrectomy or ghrelin treatment. The effect of ghrelin on meal initiation was not studied. At the end point of the study, mean body weight was 15% lower in gastrectomised mice than in sham operated mice (p Conclusions: Ghrelin replacement partially reversed the gastrectomy induced reduction in body weight, lean body mass, and body fat but not in bone mass. In sham operated mice, ghrelin only increased fat mass. Our results suggest that ghrelin is mainly concerned with the control of fat metabolism and that ghrelin replacement therapy may alleviate the weight loss associated with gastrectomy. |
| وصف الملف: | application/pdf |
| تدمد: | 0017-5749 1468-3288 |
| DOI: | 10.1136/gut.2004.058578 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ca317a0a3828b520b027bc687a069a https://doi.org/10.1136/gut.2004.058578 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....91ca317a0a3828b520b027bc687a069a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00175749 14683288 |
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| DOI: | 10.1136/gut.2004.058578 |