Dopamine D2-Like Receptors and Behavioral Economics of Food Reinforcement
| العنوان: | Dopamine D2-Like Receptors and Behavioral Economics of Food Reinforcement |
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| المؤلفون: | Jonathan L. Katz, Steven R. Hursh, Paul L. Soto, David K. Grandy, Ming Xu, Takato Hiranita |
| المصدر: | Neuropsychopharmacology. 41:971-978 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Reinforcement Schedule, Extinction, Psychological, Receptor subtype, Developmental psychology, Mice, 03 medical and health sciences, 0302 clinical medicine, Reward, Dopamine, Internal medicine, Dopamine receptor D2, medicine, Animals, Reinforcement, Receptor, Closed economy, Mice, Knockout, Pharmacology, Receptors, Dopamine D2, Extramural, Economics, Behavioral, digestive, oral, and skin physiology, Feeding Behavior, Extinction rate, Mice, Inbred C57BL, Psychiatry and Mental health, 030104 developmental biology, Endocrinology, Food, Original Article, Psychology, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Previous studies suggest dopamine (DA) D2-like receptor involvement in the reinforcing effects of food. To determine contributions of the three D2-like receptor subtypes, knockout (KO) mice completely lacking DA D2, D3, or D4 receptors (D2R, D3R, or D4R KO mice) and their wild-type (WT) littermates were exposed to a series of fixed-ratio (FR) food-reinforcement schedules in two contexts: an open economy with additional food provided outside the experimental setting and a closed economy with all food earned within the experimental setting. A behavioral economic model was used to quantify reinforcer effectiveness with food pellets obtained as a function of price (FR schedule value) plotted to assess elasticity of demand. Under both economies, as price increased, food pellets obtained decreased more rapidly (ie, food demand was more elastic) in DA D2R KO mice compared with WT littermates. Extinction of responding was studied in two contexts: by eliminating food deliveries and by delivering food independently of responding. A hyperbolic model quantified rates of extinction. Extinction in DA D2R KO mice occurred less rapidly compared with WT mice in both contexts. Elasticity of food demand was higher in DA D4R KO than WT mice in the open, but not closed, economy. Extinction of responding in DA D4R KO mice was not different from that in WT littermates in either context. No differences in elasticity of food demand or extinction rate were obtained in D3R KO mice and WT littermates. These results indicate that the D2R is the primary DA D2-like receptor subtype mediating the reinforcing effectiveness of food. |
| تدمد: | 1740-634X 0893-133X |
| DOI: | 10.1038/npp.2015.223 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91aed38c43ab3a934e2212decf45793a https://doi.org/10.1038/npp.2015.223 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....91aed38c43ab3a934e2212decf45793a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1740634X 0893133X |
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| DOI: | 10.1038/npp.2015.223 |