Redistributed versus homogenous radiotherapy dose for head and neck cancer; a treatment planning study
| العنوان: | Redistributed versus homogenous radiotherapy dose for head and neck cancer; a treatment planning study |
|---|---|
| المؤلفون: | Jan-Jakob Sonke, Erik van Werkhoven, Erik Slooten, E. Lamers, J. Heukelom, Coen R.N. Rasch |
| المساهمون: | CCA - Cancer Treatment and Quality of Life, APH - Methodology, APH - Personalized Medicine, Radiotherapy |
| المصدر: | Physics and Imaging in Radiation Oncology, Vol 3, Iss, Pp 17-20 (2017) Physics and Imaging in Radiation Oncology, 3, 17-20. Elsevier Ireland Ltd |
| بيانات النشر: | Elsevier BV, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | lcsh:Medical physics. Medical radiology. Nuclear medicine, Radiation, business.industry, lcsh:R895-920, medicine.medical_treatment, Trial protocol, Head and neck cancer, Planning target volume, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, lcsh:RC254-282, Head and neck squamous-cell carcinoma, 030218 nuclear medicine & medical imaging, Radiation therapy, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Total dose, medicine, Radiotherapy dose, Radiology, Nuclear Medicine and imaging, Radiation treatment planning, business, Nuclear medicine |
| الوصف: | Dose redistribution, where radio-resistant parts of the tumour are boosted while the border of the planning target volume receives a lower dose has the potential to increase local control in advanced head and neck squamous cell carcinoma (HNSCC). In this treatment planning study for 20 patients, standard radiotherapy (RT) of 70 Gy, was compared to redistributed RT following the ARTFORCE trial protocol (NCT01504815), i.e., a fluorodeoxyglucose-positron emission tomography (FDG-PET) based heterogeneous simultaneous-integrated-boost to a total dose of 64–84 Gy. Redistribution marginally increased the mean ipsilateral ⧹contralateral parotid dose by 1.55⧹0.55 Gy but not dose to other organs at risk. Keywords: Head and neck cancer, Radiotherapy, Dose-painting, Treatment planning |
| تدمد: | 2405-6316 |
| DOI: | 10.1016/j.phro.2017.07.002 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9164cec8d760ad8ae6e730f9bf269c41 https://doi.org/10.1016/j.phro.2017.07.002 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9164cec8d760ad8ae6e730f9bf269c41 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24056316 |
|---|---|
| DOI: | 10.1016/j.phro.2017.07.002 |