Platelet-rich plasma accelerated surgical angio-genesis in vascular-implanted necrotic bone: An experimental study in rabbits
| العنوان: | Platelet-rich plasma accelerated surgical angio-genesis in vascular-implanted necrotic bone: An experimental study in rabbits |
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| المؤلفون: | Osami Suzuki, Toru Sunagawa, Kazunori Yokota, Atsuo Nakamae, Osamu Ishida, Mitsuo Ochi |
| المصدر: | Acta Orthopaedica. 79:106-110 |
| بيانات النشر: | Medical Journals Sweden AB, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, Time Factors, Angiogenesis, medicine.medical_treatment, Neovascularization, Physiologic, Thigh, Neovascularization, Animals, Humans, Medicine, Orthopedics and Sports Medicine, Platelet-Rich Plasma, business.industry, Growth factor, Angiography, Osteonecrosis, General Medicine, Vascular bundle, medicine.anatomical_structure, Platelet-rich plasma, Surgery, Rabbits, Implant, medicine.symptom, business, Blood vessel |
| الوصف: | Platelets contain many kinds of growth factors with the ability to accelerate angiogenesis. We analyzed whether a single injection of platelet-rich plasma (PRP) would accelerate surgical angiogenesis in necrotic bone implanted with vascular tissue.We used 24 Japanese White rabbits. PRP was refined from autologous blood by separation twice with centrifugation. A removed iliac bone was frozen in liquid nitrogen to ensure complete cellular necrosis. A narrow hole was made in the bone and the saphenous vascular bundle was passed through the hole. The bone was wrapped after injection of either 1 mL (1) PRP, or (2) saline solution into the hole, and was placed subcutaneously in the thigh. In both groups, angiogenesis was compared 1 week and 2 weeks after surgery.Angiogenesis was observed along the implanted vascular bundle in both groups. At 1 and 2 weeks after surgery, both the vessel density and the average length of newly formed vessels of the experimental group were significantly greater than in the control group. Both the vessel density and the length were greater after 2 weeks than after 1 week.A single injection of PRP accelerates surgical angiogenesis in vascular-implanted necrotic bone. |
| تدمد: | 1745-3682 1745-3674 |
| DOI: | 10.1080/17453670710014842 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914993b2acc6ada6ddc9f5d14659c574 https://doi.org/10.1080/17453670710014842 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....914993b2acc6ada6ddc9f5d14659c574 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17453682 17453674 |
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| DOI: | 10.1080/17453670710014842 |